A protocol of systematic review and meta-analysis of neuromuscular electrical stimulation for interstitial cystitis.

This study will examine the effectiveness and safety of neuromuscular electrical stimulation (NMES) for the treatment of patients with interstitial cystitis (IC).

We will retrieve the following electronic databases from their commencements to the March 1, 2020 to discover all related potential studies: MEDLINE, EMBASE, Cochrane Library, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and WANFANG Database. Randomized controlled trials related to the NMES for the treatment of patients with IC will be included, regardless publication status and language. Literature selection, data collection, and study quality assessment will be independently performed by 2 authors. The extracted data will be expressed as risk ratio and 95% confidence intervals for dichotomous data, and mean difference or standard mean difference and 95% confidence intervals for continuous data. RevMan V.5.3 software will be employed for statistical analysis.

This study will summarize current high quality randomized controlled trials to appraise the effectiveness and safety of NMES for the treatment of patients with IC.

The findings of this study will provide helpful evidence to determine whether NMES is an effective treatment for patients with IC or not.

PROSPERO CRD42020170495.

Medicine. 2020 Jul 10 [Epub]

Da-Yin Chen, Ying-Xue Guo, Long-Xin Dong, Wen-Jie He, Hui-Feng Cao, Ping Wang, Cai-Fang Yue

Department of Urology, The First Affiliated Hospital of Jiamusi University., Department of Pharmacy, Jiamusi University., Department of Outpatient, The First Affiliated Hospital of Jiamusi University., Forensic Identification Center, Criminal Technology Division of Jiamusi Public Security Bureau., Department of Critical Care Medicine, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.

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