WASHINGTON, DC USA (UroToday.com) - Dr. Jeff Dome presented data demonstrating the marked improvements in survival with Wilms’ tumor, rhabdomyosarcomas of the GU tract, as well as testicular cancers.AUA 2011 - SPU: Renal outcomes in children treated with Wilm's Tumor - Session Highlights This improvement in survival has its attendant chronic health problems that are often related to the chemotherapy or the radiation therapy. Chemotherapies associated with chronic health problems include doxyrubicin, cyclophosphamide, etoposide. XRT is also associated with chronic health problems. Late effects and chronic health problems include cardiac toxicity, secondary malignancies, pulmonary toxicity, endocrine effects, musculoskeletal effects and bladder dysfunction. Thus a reappraisal of the treatments for pediatric GU malignancies is needed in an effort to maintain the cure rates but decrease the long term morbidity associated with the therapies.
Presented by Jeff Dome, MD at the 59th Annual Meeting of the Society for Pediatric Urology during the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA
Reported for UroToday by Pamela I. Ellsworth, MD, Associate Professor Surgery (Urology), Alpert Medical School of Brown University.