The Effect of Platelet-Rich Plasma on Peyronie's Disease in Rat Model

The objective of this study was to evaluate the effects of intratunical injection of platelet rich plasma (PRP) for the treatment of Peyronie's disease (PD) in a rat model.

Twenty male Sprague-Dawley rats (300-350 g) were randomly divided into 4 groups: sham, PD, PD + PRP, and PRP. The PD + PRP groups received intratunical injections with 0.1 mL PRP on day 15 (treatment) or day 0 (PRP effect). Forty-five days following transforming growth factor-beta 1 injection, rats underwent pathological examination. Tissues were evaluated histologically for fibrosis grade (Haematoxylin & Eosin staining), collagen/smooth muscle ratio (Masson Trichrome staining) and type III/type I collagen ratio (Picro-sirius red staining). Statistical analysis was performed by Kruskal-Wallis and chi-square followed by the Mann-Whitney U test for post hoc comparisons.

Significant changes were found in all 3 groups compared to the sham group (p < 0.0001 for fibrosis, p = 0.001 for collagen/smooth muscle ratio and p = 0.003 for type III/type I collagen ratio). The values in the PRP group and the findings in the PD group are similar (p = 0.122 for fibrosis, p = 0.221 for collagen/smooth muscle ratio and p = 1.0 for type III/type I collagen ratio).

This is the first study of PRP on PD. As a result of pathological examinations, PRP shows PD-like effects in rats. PRP may be a cheap, easily accessible, and an effective disease model for PD treatment research.

Urologia internationalis. 2018 Oct 12 [Epub ahead of print]

Mehmet Gokhan Culha, Erkan Erkan, Tugce Cay, Uğur Yücetaş

Department of Urology, University of Health Sciences, Okmeydani Training & Research Hospital, Istanbul, Turkey., Department of Urology, University of Health Sciences, Istanbul Training & Research Hospital, Istanbul, Turkey., Department of Pathology, University of Health Sciences, Bagcilar Training & Research Hospital, Istanbul, Turkey.

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