We report a case of bacteremia caused by a rare Helicobacter species, Campylobacter-like organism-3 (CLO-3), in a 75-year-old man with prostate cancer and indwelling urethral catheter for urinary retention.
Oral levofloxacin (500mg per day) was effective, although the results of antimicrobial susceptibility testing were unknown. Non-film-like, small, clear colonies were isolated on blood agar after 72h of microaerobic incubation at 37°C. Biochemical testing indicated that the isolates were catalase-positive, negative for nitrate reduction and urease activity, and positive for indoxyl acetate hydrolysis. The isolate was identified as CLO-3 by sequence analysis of the 16S rRNA and hsp60 genes. Although CLO-3 is known to cause enterocolitis, bacteremia due to CLO-3 has not been described. There have been an increasing number of reports of bacteremia caused by Helicobacter cinaedi and Helicobacter fennelliae which firstly reported as CLO-1 and CLO-2, and CLO-3 may represent another an emerging cause of Helicobacter-induced bacteremia.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2015 Nov 27 [Epub ahead of print]
Itaru Nakamura, Kiyofumi Ohkusu, Yoshihiro Nakagami, Masaaki Tachibana, Tetsuya Matsumoto
Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan. , Department of Microbiology, Tokyo Medical University, Tokyo, Japan. Department of Urology, Tokyo Medical University Hospital, Tokyo, Japan. , Department of Urology, Tokyo Medical University Hospital, Tokyo, Japan. , Department of Microbiology, Tokyo Medical University, Tokyo, Japan.