Prostatitis is easily diagnosed but sometimes associated with PSA measurement. An increased PSA in an asymptomatic patient may be associated with antibiotic use to eliminate the inflammatory part and to confirm prostate biopsy. It seems interesting to confirm or infirm these attitudes with a systematic review of the literature
METHOD: We performed a literature review using the words [prostatitis], [acute prostatitis], [prostate specific antigen], [PSA], in the MEDLINE, Pubmed and AMBASE database searching for articles in French or English published in the past 20 years.
RESULTS: PSA is not always increased during an acute prostatitis episode. An increased PSA in an asymptomatic man does not seem to be systematically correlated to prostate inflammation. Analyzing the studies, it seems inaccurate to measure PSA value during a febrile urinary infection episode in men. Systematic use of antibiotic to decrease PSA and not performing prostate biopsy is not relevant and may induce resistance to antibiotic and doesn't induce a reduction risk of having prostate biopsy.
CONCLUSION: PSA is unnecessary in case of febrile urinary tract infection in men.
Bruyère F, Amine Lakmichi M. Are you the author?
Service d'urologie, CHRU Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France; Université François-Rabelais PRES centre Val de Loire, 37044 Tours, France.
Reference: Prog Urol. 2013 Dec;23(16):1377-81.
Article in French.