Assessing chronic pelvic pain syndrome patients: Blood plasma factors and cortisol saliva - Abstract

Objective: The aim of this study was to identify changes in inflammatory molecules in the blood (plasma) of patients with chronic prostatitis/chronic pelvic syndrome (CP/CPPS) compared with controls.

Altered levels indicate a systemic component by possible involvement of the prostate and/or the inner pelvic floor musculature.

Material and Methods: In 32 patients with CP/CPPS and 37 controls, blood plasma levels of testosterone, macrophage migration inhibitory factor (MIF), tumour necrosis factor-α (TNF-α), TNF-β, interleukin-2 (IL-2) and IL-1β were measured by enzyme-linked immunosorbent assay. Cortisol in saliva samples was measured in the morning and late evening. All participants answered a questionnaire regarding their health profile.

Results: Significantly higher levels of MIF (p = 0.012) were detected in patients. The testosterone level was, contrary to other studies, little lower in patients (p = 0.014; age adjusted). When controls with health issues and patients with a parallel disease were excluded, the MIF and TNF-α levels were higher in the patients (p = 0.007, p = 0.016, respectively) than in controls, and the testosterone was slightly lower in patients (p = 0.047).

Conclusions: The findings show an immune response extending to the circulatory system, in which MIF makes a significant contribution to CP/CPPS. This study also indicates TNF-α as a circulatory component when excluding subjects with concomitant diseases. Both MIF and TNF-α have previously been highlighted for other diseases related to chronic pain and here also for CP/CPPS. These results provide further insights into the immunological basis of CP/CPPS.

Written by:
Lundh D, Hedelin H, Jonsson K, Gifford M, Larsson D.   Are you the author?
Systems Biology Research Center, School of Life Sciences, University of Skövde, Skövde, Sweden.

Reference: Scand J Urol. 2013 Feb 11. Epub ahead of print.
doi: 10.3109/21681805.2013.769460

PubMed Abstract
PMID: 23394140

Go "Beyond the Abstract" - Read an article written by the authors for Prostatitis Section







Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.