Assessment of hormonal activity in patients with premature ejaculation

Premature ejaculation is considered the most common type of male sexual dysfunction. Hormonal controls of ejaculation have not been exactly elucidated. The aim of our study is to investigate the role of hormonal factors in patients with premature ejaculation.

Sixty-three participants who consulted our outpatient clinics with complaints of premature ejaculation and 39 healthy men as a control group selected from volunteers were included in the study. A total of 102 sexual active men aged between 21 and 76 years were included. Premature ejaculation diagnostic tool questionnaires were used to assessment of premature ejaculation. Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, total and free testosterone, thyroid-stimulating hormone, free triiodothyronine and thyroxine were measured.

Thyroid-stimulating hormone, luteinizing hormone, and prolactin levels were significantly lower in men with premature ejaculation according to premature ejaculation diagnostic tool (p=0.017, 0.007 and 0.007, respectively). Luteinizing hormone level (OR, 1.293; p=0.014) was found to be an independent risk factor for premature ejaculation.

Luteinizing hormone, prolactin, and thyroid-stimulating hormone levels are associated with premature ejaculation which was diagnosed by premature ejaculation diagnostic tool questionnaires. The relationship between these findings have to be determined by more extensive studies.

International braz j urol : official journal of the Brazilian Society of Urology. 2016 Sep 01 [Epub ahead of print]

Lutfi Canat, Akif Erbin, Masum Canat, Mehmet Dinek, Turhan Caskurlu

Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey., Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey., Department of Endocrinology, Bayburt State Hospital, Bayburt, Turkey., Department of Urology, Kastamonu State Hospital, Kastamonu, Turkey., Department of Urology, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.