Association between long-term erectile dysfunction and biochemical recurrence after permanent seed I(125) implant brachytherapy for prostate cancer. A longitudinal study of a single-institution

We aimed to investigate the predictive factor of erectile dysfunction (ED) in prostate cancer (PCa) patients who underwent low-dose permanent I(125) seed implant brachytherapy and to investigate if ED could represent a patient's reported outcome measures (PROMs) of efficacy of BT and indirectly associated with biochemical recurrence free survival (BRFS).

From 2000 to 2012, 176 consecutive patients with low-risk PCa underwent BT. ED was evaluated with the International Index of Erectile Function (IIEF-5). Cox regression analysis was performed to assess significant predictors of mild-to-severe ED and BRFS after BT, including covariates. The 10-year actuarial rate of ED was 66%. Subjects with severe ED had higher values of D90 (183. 0 versus 177. 0; p < 0. 05) and V100% (40. 1 versus 31. 4; p < 0. 05) compared with normal. At the multivariate logistic regression analysis, D90 (OR: 1. 10; p < 0. 05) was an independent predictor of ED. Multivariate Cox-regression analysis did not demonstrate significant association between erectile preservation and biochemical recurrence (BCR) after 10 years of follow up (HR: 2. 15; p = 0. 20), while D90 ≤ 180 Gy independently predicted BCR (HR: 4. 65; [95%CI: 1. 25-17. 34]; p < 0. 05). Erectile preservation should be addressed as valuable PROMs after permanent seed I(125) implant, but it is not associated with better BRFS.

The aging male : the official journal of the International Society for the Study of the Aging Male. 2015 Sep 16 [Epub ahead of print]

Giuseppe Morgia, Tommaso Castelli, Salvatore Privitera, Chaled Al-Nakib, Vincenzo Favilla, Francesco Marchese, Sebastiano Cimino, Giorgio Ivan Russo

a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy. , a Department of Urology , University of Catania , Catania , Italy.

PubMed

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe