To evaluate associations of NSAID use and risk of ED, considering indications for NSAID use.
Data are from 4,726 men in the placebo arm of the Prostate Cancer Prevention Trial (PCPT) without evidence of ED at baseline.
Incident ED was defined as mild/moderate (decrease in normal function) and severe (absence of function). Proportional hazards models were used to estimate covariate-adjusted associations of NSAID-related medical conditions and time-dependent NSAID use with ED risk.
Arthritis (HR: 1.56), chronic musculoskeletal pain (HR: 1.35), general musculoskeletal complaints (HR:1.36), headaches (HR:1.44), sciatica (HR:1.50), and atherosclerotic disease (HR:1.60) were all significantly associated with increased risk of, mild/moderate ED, while only general musculoskeletal complaints (HR:1.22), headaches (HR:1.47) and atherosclerotic disease (HR:1.60) were associated with increased risk of severe ED. Non-aspirin NSAID use was associated with an increased risk of mild/moderate ED (HR: 1.16, p=0.02) and Aspirin use was associated with an increased risk of severe ED (HR: 1.16, p=0.03, respectively). Associations of NSAID use with ED risk were attenuated after controlling for indications of NSAID use.
The modest associations of NSAID use with ED risk in this cohort were likely due to confounding indications of NSAID use. NSAID use was not associated with ED risk.
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BJU international 2015 Aug 25 [Epub ahead of print]
Darshan P Patel, Jeannette M Schenk, Amy Darke, Jeremy B Myers, William O Brant, James M Hotaling
Division of Urology, University of Utah, Salt Lake City, UT, USA , The Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA , SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA , Division of Urology, University of Utah, Salt Lake City, UT, USA , Division of Urology, University of Utah, Salt Lake City, UT, USA , Division of Urology, University of Utah, Salt Lake City, UT, USA