To evaluate the safety and efficacy of platelet rich plasma (PRP) injections as a therapeutic modality for mild to moderate erectile dysfunction.
A placebo controlled study of 100 cases with mild to moderate erectile dysfunction. Participants were allocated to 2 groups; the PRP group received 3 injections (3ml each corpus) and the interval between injections was 15 days, while the Placebo (Saline) group received 6ml saline injected intracavernous. Post injection follow up lasted 6 months.
Compared to the placebo group, the PRP group demonstrated a significant improvement at the 1 and 3 months follow up that slightly dropped at the 6 months follow up (p<0.001). The improvement was evident in the duplex parameters, IIEF-EF, SEP Q2 and 3. At 1-month post-treatment follow up (76%) patients in the PRP group had an improved IIEF-EF as they attained a MCID compared to (18%) in the saline group. At the 3-months post-treatment follow up, (72%) patients achieved a MCID in the PRP group versus (16%) in saline group then dropped to (70%) in the PRP group versus (16%) in saline group at the 6-months post-treatment follow up. Patients' overall and intercourse satisfaction levels were higher in the PRP group than the placebo group as demonstrated with the higher IIEF score Q6, 7, 8 and IIEF score Q13, 14 respectively with the maximum improvement reported at the 3-months follow up. No reports of plaque formation, subcutaneous bruising or any other major side effects among participants.
PRP is a safe and promising method for improving of mild to moderate erectile dysfunction.
Urology. 2023 Feb 01 [Epub ahead of print]
Hussein Shaher, Abdallah Fathi, Salah Elbashir, Shabieb A Abdelbaki, Tarek Soliman
Urology and Andrology Departement, Faculty of Medicine, Benha University. Electronic address: ., Urology and Andrology Departement, Faculty of Medicine, Benha University. Electronic address: ., Urology and Andrology Departement, Faculty of Medicine, Benha University. Electronic address: ., Urology and Andrology Departement, Faculty of Medicine, Benha University. Electronic address: ., Urology and Andrology Departement, Faculty of Medicine, Benha University. Electronic address: .