The significant discontinuation rate of available therapies and the paucity of curative options promoted the research on potential novel treatments suitable for erectile dysfunction patients. The aim of this study was to provide a summary of available evidence regarding the news and future perspectives related to the non-surgical treatment of erectile dysfunction. A narrative review of the literature was performed. A comprehensive search in the MEDLINE, Embase, and Scopus databases was done. Papers in English-language, published until April 2022, were included. No chronological restriction was applied. Retrospective and prospective clinical studies, as well as meta-analyses, were considered. Oro-dispersible formulations of phosphodiesterase type 5 inhibitors are particularly indicated in patients who have difficulty in swallowing solid dosage form; in addition, they constitute a discrete route of administration not requiring water. Low-intensity extracorporeal shock wave therapy is indicated in mild vasculogenic erectile dysfunction and in patients with vasculogenic erectile dysfunction poorly responsive to phosphodiesterase type 5 inhibitors. Stem cell therapy, platelet-rich plasma injections, and gene therapy seem promising regenerative treatments for selected patients with erectile dysfunction. Novel oral formulations of drugs commonly used in erectile dysfunction patients have recently become part of standard clinical practice. Regenerative treatments have been emerging in recent years and could become routine curative options in the near future. Further well-designed randomized controlled trials are needed to provide conclusive evidence on this topic and guide appropriate recommendations.
International journal of impotence research. 2022 Jul 27 [Epub ahead of print]
Celeste Manfredi, Fabio Castiglione, Mikkel Fode, Michal Lew-Starowicz, Javier Romero-Otero, Carlo Bettocchi, Giovanni Corona, ESSM Scientific Collaboration and Partnership (ESCAP)
Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. ., Department of Urology, University College London Hospitals NHS Trust, London, UK., Department of Urology, Copenhagen University Hospital-Herlev and Gentofte Hospital, Herlev, Denmark., Department of Psychiatry, Centre of Postgraduate Medical Education, Warsaw, Poland., ROC Clinic, Madrid, Spain., Department of Urology, University of Foggia, Foggia, Italy., Endocrinology Unit, Medical Department, Maggiore-Bellaria Hospital, Bologna, Italy.