To investigate the influence of lifestyle, metabolic syndrome (MetS) on the prevalence of benign prostatic hyperplasia (BPH) requiring treatment using a large historical cohort.
This study included 130,454 men selected from the National Health Insurance Service health checkup database. Men were divided into the two groups according to the presence of MetS. A generalized estimating equation was performed to assess the predictors of BPH requiring treatment after adjusting other variables.
The prevalence of BPH requiring treatment was significantly higher in men with MetS except in men aged < 50 years. Multivariable analysis showed that MetS was associated with higher prevalence of BPH requiring treatment regardless of age, and that a low income was associated with a lower prevalence in men aged ≥ 60 years. Alcohol consumption was negatively associated with prevalence of BPH requiring treatment in all age groups except in men aged < 50 years. Among the MetS components, low high density lipoprotein cholesterol (HDL-cholesterol) levels showed the strongest association with the prevalence of BPH requiring treatment in all age categories, although all MetS components were correlated with an increased prevalence of BPH requiring treatment, particularly in men aged ≥ 50 years.
MetS and its components, particularly low HDL-cholesterol levels, were strongly correlated with an increased prevalence of BPH requiring treatment. In addition, moderate alcohol intake and elderly men from lower socioeconomic strata were associated with a decreased prevalence of BPH requiring treatment in our cohort. This article is protected by copyright. All rights reserved.
BJU international. 2018 Aug 19 [Epub ahead of print]
Sangjun Yoo, Sohee Oh, Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
Department of Urology, Seoul National University Boramae Medical Center, Seoul, Republic of Korea., Department of Biostatistics, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.