The prevalence of urinary stone disease (USD) and asthma is rising and has recently been associated in a pediatric population.
To investigate the association between asthma and USD in a nationally representative adult population.
We analyzed the National Health and Nutrition Examination Survey 2007-2014, a US population-based cross-sectional study. A history of asthma and USD was obtained by self-report to questionnaires. USD severity was represented by graded stratification into non-stone formers, single stone formers, and recurrent stone formers (>2 stones).
Odds ratios (ORs) for asthma were calculated for respondents with USD and separately for the graded USD groups. Survey-weighted logistic regression models included adjustments for demographics (model A), medical information (model B), and for relevant medications (model C).
A total of 20 906 participants aged ≥20 yr were included in the analysis. Of these, 9.2% reported of having a history of kidney stones. Logistic regression analysis adjusted for demographics, medical conditions, and medications showed that stone formers had significantly increased odds of asthma (odds ratio=1.23; 95% confidence interval: 1.03-1.47; p=0.023). Separate logistic regression analysis demonstrated a graded association between single and recurrent stone formers and the odds of having asthma (p=0.01), which remained significant in the 20-50-yr-old population and the diabetic population, especially for recurrent stone formers. Causal relationships were limited by cross-sectional nature of the study.
Increasing severity of USD is associated with an increase in odds for asthma among American adults, providing impetus for future studies into the mechanisms explaining this phenomenon.
In this report, we looked at self-reported histories of asthma and urinary stone disease (USD) using information from a large US population. We found that asthma was associated with USD; however, further studies are needed to elucidate this relationship.
European urology focus. 2018 Aug 07 [Epub ahead of print]
Justin A Lee, Matthew K Abramowitz, Naama Kipperman, Beth A Drzewiecki, Michal L Melamed, Joshua M Stern
Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: ., Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine/Nephrology, Montefiore Medical Center, Bronx, New York, USA., Department of Epidemiology & Population Health, Montefiore Medical Center, Bronx, New York, USA., Albert Einstein College of Medicine, Bronx, New York, USA; Department of Urology, Montefiore Medical Center, Bronx, New York, USA., Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine/Nephrology, Montefiore Medical Center, Bronx, New York, USA; Department of Epidemiology & Population Health, Montefiore Medical Center, Bronx, New York, USA.