Bladder Cancer

Orthotopic Neobladder Reconstruction: Patient Selection And Perspectives.

Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure that may be performed in a patient with bladder cancer following a radical cystectomy. The selection of a patient for an ONB reconstruction is strict as not everyone may be suitable to undergo this complex surgery.

Genetic variant of MAML2 in the NOTCH signaling pathway and the risk of bladder cancer: A STROBE-compliant study.

The NOTCH signaling pathway plays a crucial role in cell phenotype and transformation. Single nucleotide polymorphisms (SNPs) may regulate gene expression to trigger bladder cancer susceptibility. Here, we aimed to explore the relationships between genetic variants in the NOTCH pathway and bladder cancer progression.

Systematic Review: Genetic Associations for Prognostic Factors of Urinary Bladder Cancer.

Many germline associations have been reported for urinary bladder cancer (UBC) outcomes and prognostic characteristics. It is unclear whether there are overlapping genetic patterns for various prognostic endpoints.

A Randomized Phase II Trial of Vinflunine and Gemcitabine Versus Carboplatin and Gemcitabine in Cisplatin-Ineligible Patients with Advanced Urothelial Carcinoma - Expert Commentary

A significant number of patients with locally advanced and metastatic urothelial cancer (aUC) are not eligible for cisplatin-based chemotherapy.

Comparison of Neoadjuvant and Adjuvant Chemotherapy in Muscle-invasive Bladder Cancer.

We use observational methods to compare impact of perioperative chemotherapy timing (ie, neoadjuvant and adjuvant) on overall survival (OS) in muscle-invasive bladder cancer because there is no head-to-head randomized trial, and patient factors may influence decision-making.

Is the En Bloc Transurethral Resection More Effective than Conventional Transurethral Resection for Non-Muscle-Invasive Bladder Cancer? A Systematic Review and Meta-Analysis.

En bloc transurethral resection (ERBT) is a major topic of discussion as an alternative to conventional transurethral resection (cTURBT) for the treatment of non-muscle-invasive bladder cancer (NMIBC) addressing the limitations of cTURBT.

Study Progress of Radiomics With Machine Learning for Precision Medicine in Bladder Cancer Management.

Bladder cancer is a fatal cancer that happens in the genitourinary tract with quite high morbidity and mortality annually. The high level of recurrence rate ranging from 50 to 80% makes bladder cancer one of the most challenging and costly diseases to manage.

Increasing Rates of Perioperative Chemotherapy are Associated with Improved Survival in Men with Urothelial Bladder Cancer with Prostatic Stromal Invasion - Beyond the Abstract

The use of perioperative chemotherapy (CHT) has received little attention in patients with pT4a urothelial bladder cancer (UCUB). Despite international guidelines recommending the use of either neoadjuvant or adjuvant chemotherapy, if no neoadjuvant chemotherapy has been given1,2 before or after radical cystectomy3 and several studies showing its benefit on survival in predominantly pT2-3 patients,4-10 the effect of perioperative CHT on overall survival (OS) and cancer-specific survival (CSS) in patients with prostatic stromal invasion is based on very limited number of observations and therefore lacks robustness. In consequence, we examined this relationship in a contemporary cohort of patients with UCUB and prostatic stromal invasion identified within the Surveillance, Epidemiology and End Results (SEER) database (2004-2016).

Adaptive Radiotherapy for Carcinoma of the Urinary Bladder: Long-term Outcomes With Dose Escalation - Beyond the Abstract

Invasive bladder cancer has traditionally been treated with radical cystectomy, which is a significantly morbid surgery. Radiotherapy (RT) has been the cornerstone of trimodality therapy as an alternative to avoid surgery and preserve the bladder.

Safety and efficacy of en bloc transurethral resection versus conventional transurethral resection for primary nonmuscle-invasive bladder cancer: a meta-analysis.

The purpose of this meta-analysis is to compare the safety and efficacy of en bloc transurethral resection of bladder tumor (EBRT) versus conventional transurethral resection of bladder tumor (CTURBT).