To analyze the association between salivary melatonin rhythm and prostate cancer (PCa).
A total of 40 PCa cases and 41 controls from CAPLIFE study were analyzed to determine the salivary melatonin rhythm through 6 saliva samples. Amplitude (maximum melatonin peak) was categorized as low or high using the cut-off point median of the controls. Acrophase (time of maximum melatonin peak) was classified as early or late using the same criteria. In addition, the following data were collected: characteristics related to sleep habits, clinical and sociodemographic information. Melatonin rhythms were represented for cases and controls and analyzed according to urinary symptoms, tumor aggressiveness, and tumor extension. Variations in melatonin levels were estimated using generalized estimating equations (GEE) on the ln-transformed values. To estimate the association between amplitude, acrophase, and PCa, adjusted aOR and 95% CI were calculated using logistic regression models.
The mean age was 67.0 years (SD 7.3) for cases and 67.5 (SD 5.5) for controls. Melatonin levels were always lower in PCa cases than in controls. On average, melatonin levels in cases were -64,0% (95% CI -73.4, -51.4) than controls. PCa cases had lower amplitude, 26.0 pg/ml (SD 27.8) vs 46.3 pg/ml (SD 28.2) (p-value<0.001). A high amplitude was associated with a decreased risk of PCa, aOR=0.31 (95% CI 0.11, 0.86), while a late acrophase could be increased risk of PCa, aOR=2.36 (95% CI 0.88, 6.27).
PCa patients always had lower melatonin levels than men without PCa, independent of urinary symptomatology or extension and aggressiveness of the tumor.
The Journal of urology. 2021 Oct 25 [Epub ahead of print]
Macarena Lozano-Lorca, Rocío Olmedo-Requena, Miguel Rodríguez-Barranco, Daniel Redondo-Sánchez, Antonio Jiménez-Pacheco, Fernando Vázquez-Alonso, Emilia Arana-Asensio, María-José Sánchez, José Fernández-Martínez, Darío Acuña-Castroviejo, José Juan Jiménez-Moleón
Universidad de Granada, Departamento de Medicina Preventiva y Salud Pública, Granada, Spain., Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain., Urology Department, San Cecilio University Hospital, Granada, Spain., Urology Department, Virgen de las Nieves University Hospital, Granada, Spain., Pinos Puente Primary Health Care Centre, Distrito Sanitario Granada-Metropolitano, Granada, Spain., Centro de Investigación Biomédica, Departamento de Fisiología, Facultad de Medicina, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain.