Purpose: To compare two different biopsy devices for upper tract urothelial carcinoma (UTUC) and evaluate the pathologic result obtained by these devices.
Patients and Methods: From January 2008 to December 2010, 414 ureteroscopies were performed and 504 biopsies were taken for evaluation of UTUC. Two biopsy devices were compared: 2.4F stainless steel flat wire basket and 3F cup biopsy forceps. The effect of biopsy device on obtaining an adequate pathological specimen was evaluated using univariate and multivariate binary logistic regression analysis. We also investigated whether tumor grade determination was affected by biopsy device among patients with diagnostic biopsy.
Results: Diagnosis was successful in 63% and 94% in the forceps and basket groups, respectively (p< 0.0001). Among biopsies with a definite diagnosis of UTUC, specific grade was determined in 80% and 93% in the forceps and basket groups, respectively (p=0.033). In sub-group analysis of tumors larger than 10 mm in diameter, diagnosis was obtained in 80% and 94% in the forceps and basket groups, respectively (p=0.037). Cytologic evaluation was found to increase diagnostic rates.
Conclusions: Stainless steel flat wire basket was shown to be superior to the 3F cup biopsy forceps in terms of obtaining tissue diagnosis and providing specific grade.
Written by:
Kleinmann N, Healy KA, Hubosky SG, Margel D, Bibbo M, Bagley D. Are you the author?
Thomas Jefferson University, Urology, 1025 Walnut Street, Suite 1112 College Building, Philadelphia, Pennsylvania, United States, 19107.
Reference: J Endourol. 2013 Sep 2. Epub ahead of print.
doi: 10.1089/end.2013-0220.ECC13
PubMed Abstract
PMID: 23998916
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