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TAT-10: Spectroscopic and Computational Studies of Actinium Coordination Chemistry

Kanazawa, Japan (UroToday.com) Ac225 is a very promising isotope for targeted alpha therapy. Production of efficient, pure conjugates would benefit from a better understanding of the basic actinium chemistry. In contrast to the tracer-level quantities of Ac225, Ac227 (half-life 22y) is available in microgram quantities which enables traditional chemical techniques. Using our stock of 150 mg (10 mCi) of Ac227, we have developed multiple spectroscopic and theoretical approaches to understand Ac coordination chemistry.

The limited supply of Ac227 requires us to fully recover the isotope after all processing and measurement thus ruling out any destructive measurements. Despite these challenges, we have completed the first X-ray absorption fine structure (XAFS) and nuclear magnetic resonance (NMR) measurements of Ac compounds. These studies contribute to understanding of Ac coordination chemistry both with simple ligands and popular chelators.

Presented By: Benjamin W. Stein from Los Alamos National Laboratory, Chemistry Division, Los Alamos, NM

Written By: William Carithers, Lawrence Berkeley National Laboratory

at the 10th International Symposium on Targeted Alpha Therapy (TAT-10)  May 31 - June 1, 2017 - Kanazawa, Japan.