SUFU 2021: Distinguishing Features of the Urinary Bacterial Microbiome in Patients With Neurogenic Bladder

(UroToday.com) This was a prospective cross-sectional study of individuals with neurogenic bladder who performed intermittent catheterization (CIC, n=51) or utilized an indwelling catheter (n=16) that aimed to characterize the microbiota and to evaluate differences based on the type of bladder management or frequency of symptomatic urinary tract infections (UTI).

All patients were without symptomatic UTI at the time of the study visit and provided a catheterized urine sample. 92 patients were recruited and submitted urine for analysis. Subsampling to 1,203 sequence reads per sample resulted in the elimination of 23 samples from the analysis due to low signal. There were no differences in demographics or urologic management between the 69 patients included in the analysis.

An unknown genus of Enterobacteriaceae and Escherichia was the most prevalent genera. In one linear discriminate analysis, Pseudomonas was identified as being differentially abundant among patients with indwelling catheters relative to clean intermittent catheterization (CIC). Aerococcus was differentially abundant among males compared to females. Urinary microbial community composition (beta diversity) did not vary significantly between groups. Patients performing CIC have a less diverse microbiome than those with indwelling catheters and are less likely to have Pseudomonas. 

Presented by: Giulia I. Lane, Alyssa Gracely, Christine Bassis, Paholo Barboglio Romo, J. Quentin Clemens, Priyanka Gupta, Diana O'Dell, John T. Stoffel, Anne P. Cameron, University of Michigan, Ann Arbor, MI

Written by: Diane K. Newman, DNP, CRNP, FAAN, BCB-PMD, Nurse Practioner and Co-Director, Penn Center for Continence and Pelvic Health Adjunct Professor of Urology in Surgery during the 2021 Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) Winter Meeting.
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