SIU 2017: Correlation between Multiparametric MRI PIRADS Scores and Prostate Carcinoma Grade Grouping on Transperineal Template +/- Targeted Biopsy

Lisbon, Portugal ( In this study the authors correlated 3T multiparametric MRI PIRADS results with transperineal template biopsy grade group scores. This data was also used to produce sensitivity and specificity results of 3T multiparametric MRI for the detection of clinically significant prostate cancer (Grade Group 2 or greater).

Between January 2013 and March 2017, 1733 PIRADS-scored multiparametric MRI reports from a single radiologist in a prospective database were analyzed. 762 men subsequently underwent 806 transperineal template biopsies within 12 months of their MRI, with MRI-biopsy targeting performed in 45.3%. Their pathology reports were prospectively stored in the same database and used as the comparator. PIRADS scores of 4 or 5 were considered positive, and PIRADS scores of 1 or 2 considered negative. 96 PIRADS 3 scores, representing an equivocal result, were removed to yield 710 data points for sensitivity and specificity analysis.

The sensitivity and specificity results were 85.6% (95%CI: 81.80% to 88.94%) and 67.5% (95%CI: 61.99% to 72.73%) respectively, for the detection of clinically significant prostate cancer.

The authors concluded that increasing PIRADS scores correlated with both increased detection of clinically significant disease and higher grade groups.

Presented by: Miller R
Affiliation: Alfred Hospital, Monash University, Clayton, Australia

Written by: Hanan Goldberg, MD, Urologic Oncology Fellow (SUO), University of Toronto, Princess Margaret Cancer Centre.Twitter: @GoldbergHanan at the 37th Congress of Société Internationale d’Urologie - October 19-22, 2017- Lisbon, Portugal