Research at ESMO Virtual Congress 2020 Highlights Significant Progress in Cancers with High Unmet Medical Need

Late-breaking data from pivotal Phase 3 CheckMate -577 and CheckMate -649 trials to be featured in ESMO Presidential Symposium III and highlight potential for Opdivo (nivolumab) and Opdivo-based regimens to change standard of care in early and advanced stages of certain esophageal and gastric cancers

Detailed results from CheckMate -9ER, presented in partnership with Exelixis, Inc. and featured in ESMO Presidential Symposium I, and four-year follow-up data from CheckMate -214 underscore the potential of Opdivo-based combinations to significantly improve survival among patients with advanced renal cell carcinoma

Late-breaking patient-reported outcomes from CheckMate -9LA examine impact of Opdivo plus Yervoy (ipilimumab) combined with limited chemotherapy on health-related quality of life in patients with metastatic non-small lung cancer (NSCLC)

Bristol Myers Squibb to Host Virtual Investor Event on Sept 21 to Discuss ESMO Highlights

San Francisco, CA (UroToday.com) -- Bristol Myers Squibb announced the presentation of research spanning 15 different cancers at the upcoming European Society for Medical Oncology (ESMO) Virtual Congress 2020, reinforcing the depth and breadth of its oncology development program, leadership in immuno-oncology, and commitment to delivering value to patients and health systems by discovering potential options to improve long-term outcomes in cancer patients. The virtual congress will take place from September 19 to 21, 2020.


Presentations will highlight Bristol Myers Squibb’s research aimed at addressing cancer through clinical data evaluating Opdivo (nivolumab) as an adjuvant therapy, Opdivo plus Yervoy (ipilimumab) as a first-line treatment, and Opdivo-based combinations across an expanding range of cancer types with the goal of advancing durable therapeutic outcomes for patients in need.

Bristol Myers Squibb will also present data exploring various novel tumor targets in early-stage pipeline therapies and novel combinations in cancers including non-Hodgkin lymphoma, extensive-stage small cell lung cancer, diffuse large B-cell lymphoma, and glioblastoma, and nearly 20 presentations will share health economic and real-world research on the clinical and economic impact of Bristol Myers Squibb’s therapies.

Overall, data from more than 67 company-sponsored studies will be presented at the meeting, including 12 late-breaking abstracts and 14 proffered paper presentations. The volume and diversity of these data highlight the role of Bristol Myers Squibb as a company dedicated to transforming the lives of patients with different types of cancer through science.

Key data being presented by Bristol Myers Squibb and its partners at the ESMO Virtual Congress 2020 include:

Renal Cell Carcinoma
  • First disclosure of detailed Phase 3 CheckMate -9ER efficacy and safety results for Opdivo in combination with Exelixis’ CABOMETYX® (cabozantinib) versus sunitinib in previously untreated advanced renal cell carcinoma (RCC); CheckMate -9ER results will be featured as part of an ESMO Presidential Symposium and in the official Press Programme.
  • Four-year follow-up from Phase 3 CheckMate -214 study of Opdivo plus Yervoy compared with sunitinib in patients with previously untreated advanced or metastatic RCC; CheckMate -214 represents longest follow-up from a Phase 3 trial of an immunotherapy-based combination in previously untreated advanced RCC.

Gastrointestinal Cancers
  • First disclosure of Phase 3 CheckMate -577 disease-free survival results for adjuvant Opdivo versus placebo for patients with resected esophageal or gastroesophageal junction cancer following neoadjuvant chemoradiation therapy; CheckMate -577 results will be featured as part of an ESMO Presidential Symposium and in the official Press Programme.
  • First disclosure of Phase 3 CheckMate -649 overall survival and progression-free survival results for Opdivo plus chemotherapy compared with chemotherapy alone as a first-line treatment for metastatic gastric cancer, gastroesophageal junction cancer or esophageal adenocarcinoma; CheckMate -649 results will be featured as part of an ESMO Presidential Symposium and in the official Press Programme.

Lung Cancer
  • Patient-reported outcomes on health-related quality of life from the Phase 3 CheckMate –9LA trial of Opdivo plus Yervoy in combination with two cycles of chemotherapy versus chemotherapy in patients with metastatic advanced non-small cell lung cancer (NSCLC).
  • Analyses in Asian patients with advanced NSCLC from both CheckMate –9LA and CheckMate-227, which investigated Opdivo plus Yervoy in combination with two cycles of chemotherapy versus chemotherapy and Opdivo plus Yervoy versus chemotherapy as a first-line treatment, respectively.

Melanoma
  • Four-year results from CheckMate -238 evaluating Opdivo versus Yervoy in adjuvant melanoma and five-year characterizations of complete responses from CheckMate -066, CheckMate -067 and CheckMate -069 studies evaluating Opdivo plus Yervoy or Opdivo alone in advanced melanoma.
“Bristol Myers Squibb has made important progress in demonstrating the significant impact our treatments can have on long-term survival and patient outcomes in numerous cancers,” said Samit Hirawat, M.D., executive vice president, chief medical officer, global drug development, Bristol Myers Squibb. “New data we are presenting at ESMO will highlight the potential to change the standard of care for certain cancers, demonstrate the value our therapies can bring to patients, and showcase how we are defining the future of medicine. We are also grateful for the tireless support from and collaboration with the cancer community, especially from investigators and patients, without whom our research would not be possible.”
Virtual Investor Event

Bristol Myers Squibb will host a virtual Investor Event on Monday, September 21, 2020, at 4:30 p.m. EDT to discuss data presented at the European Society of Medical Oncology (ESMO). Company executives will provide an overview of data presented and address questions from investors and analysts.

Select Bristol Myers Squibb studies at the ESMO Virtual Congress 2020 to include:
*All times noted are Central European Summer Time (CEST)

Gastrointestinal
  • Nivolumab (NIVO) plus chemotherapy (CT) versus CT in first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC)/esophageal adenocarcinoma (EAC): first results of the CheckMate 649 study
    Author: M. Moehler
    Abstract: #LBA6
    Presidential Symposium III, Channel 1
    Presentation Time: Monday, September 21, 18:30-18:42 CEST
  • Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiation therapy (CRT): first results of the CheckMate 577 study
    Author: R. J. Kelly
    Abstract: #LBA9
    Presidential Symposium III, Channel 1
    Presentation Time: Monday, September 21, 19:31-19:43 CEST
  • A nationwide population-based study comparing treatment patterns and outcomes in synchronous versus metachronous metastatic esophageal and gastric adenocarcinoma
    Author: M. Pape
    Abstract: #1465P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • The humanistic burden reported by patients with unresectable locally advanced or metastatic (adv/met) Gastric Cancer (GC), Gastroesophageal Junction Cancer (GEJC) and Esophageal Adenocarcinoma (EAC): An international real-world survey
    Author: J. Hall
    Abstract: #1469P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Impact on work productivity in unresectable locally advanced or metastatic gastric cancer, gastroesophageal junction cancer and esophageal adenocarcinoma patients and their caregivers
    Author: H. Xiao
    Abstract: #1433P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • The experience associated with caregiving for patients with intermediate stage hepatocellular carcinoma (HCC) receiving transcatheter arterial chemoembolisation (TACE) treatment
    Author: J. Edeline
    Abstract: #1011P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)

Genitourinary
  • Nivolumab + cabozantinib vs sunitinib in first-line treatment for advanced renal cell carcinoma: first results from the randomized phase 3 CheckMate 9ER trial
    Author: T. K. Choueiri
    Abstract: #696O
    Presidential Symposium I, Channel 1
    Presentation Time: Saturday, September 19, 19:34-19:46 CEST
  • Nivolumab + ipilimumab (N+I) vs sunitinib (S) for first-line treatment of advanced renal cell carcinoma (aRCC) in CheckMate 214: 4-year follow-up and subgroup analysis of patients (pts) without nephrectomy
    Author: L. Albiges
    Abstract: #711P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Nivolumab (N) alone or in combination with ipilimumab (I) in patients (pts) with platinum-pretreated metastatic urothelial carcinoma (mUC): extended follow-up from CheckMate 032
    Author: P. Sharma
    Abstract: #749P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • A phase 3, randomized, double-blind trial of nivolumab or placebo combined with docetaxel for metastatic castration-resistant prostate cancer (mCRPC; CheckMate 7DX)
    Author: C. G. Drake
    Abstract: #690TiP
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Treatment-free survival, with and without toxicity, after immuno-oncology vs targeted therapy for advanced renal cell carcinoma (aRCC): 42-month results of CheckMate 214
    Author: M. Regan
    Abstract: #713P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Time to deterioration in quality of life in previously untreated patients with advanced renal cell carcinoma (aRCC) in CheckMate 214
    Author: D. Cella
    Abstract: #714P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Comparison of long-term survival and cost-effectiveness (CE) of first-line (1L) treatment options in advanced renal cell carcinoma (aRCC) with intermediate or poor (I/P) prognostic risk
    Author: T. K. Choueiri
    Abstract: #717P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)

Lung Cancer
  • First-line nivolumab (NIVO) + ipilimumab (IPI) in combination with 2 cycles of platinum-based chemotherapy (chemo) vs 4 cycles of chemo in advanced non-small cell lung cancer (NSCLC): Patient-reported outcomes (PROs) from CheckMate 9LA
    Author: M. Reck
    Abstract: #LBA59
    Mini Oral Session: NSCLC, metastatic
    Presentation Time: Friday, September 18 (On-Demand)
  • First-line (1L) nivolumab (NIVO) + ipilimumab (IPI) + chemotherapy (chemo) in Asian patients (pts) with advanced non-small cell lung cancer (NSCLC) from CheckMate 9LA
    Author: T. John
    Abstract: #1311P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • First-line (1L) nivolumab (NIVO) plus ipilimumab (IPI) in Asian patients with advanced non-small cell lung cancer (aNSCLC) in CheckMate 227
    Author: K. O'Byrne
    Abstract: #1274P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • CheckMate 73L: A phase 3 study comparing nivolumab (NIVO) plus concurrent chemoradiotherapy (CCRT) followed by NIVO ± ipilimumab (IPI) versus CCRT followed by durvalumab (DURV) for previously untreated, locally advanced (LA) stage III non-small cell lung cancer (NSCLC)
    Author: D. De Ruysscher
    Abstract: #1255TiP
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Trial-based costs of all-cause adverse events in first-line therapy for advanced non-small-cell lung cancer: findings from CheckMate-227
    Author: S. Lubinga
    Abstract: #1282P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Trial-based costs of all-cause adverse events in first-line therapy for advanced non-small-cell lung cancer: findings from CheckMate-9LA
    Author: D. Stenehjem
    Abstract: #1316P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Pathologic response as early endpoint for survival following neoadjuvant therapy (NEO-AT) in resectable non-small cell lung cancer (rNSCLC): Systematic literature review and meta-analysis
    Author: N. Waser
    Abstract: #1243P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Nivolumab treatment in advanced non-small cell lung cancer (aNSCLC): real-world 3-year outcomes within overall and special populations (the UNIVOC study)
    Author: J. Assié
    Abstract: #1276P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Long-term survival and health-related quality of life in patients treated with nivolumab for advanced non-small cell lung cancer: a wide prospective French real-world study (EVIDENS)
    Author: F. Barlesi
    Abstract: #1325P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Integrating patients’ quality of life (QoL) into clinical practice: a Delphi method-based consensus among French physicians managing lung cancer patients
    Author: V. Westeel
    Abstract: #1569P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Treatment patterns and outcomes in malignant pleural mesothelioma (MPM) in England: A nationwide CAS registry analysis from the I-O Optimise initiative
    Author: P. Baas
    Abstract: #1909P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)

Melanoma
  • Adjuvant nivolumab (NIVO) vs ipilimumab (IPI) in resected stage III/IV melanoma: 4-yr recurrence-free and overall survival (OS) results from CheckMate 238
    Author: J. Weber
    Abstract: #1076O
    Proffered Paper Session: Melanoma and Other Skin Tumours, Channel 2
    Presentation Time: Saturday, September 19, 17:28-17:40 CEST
  • 5-year characterization of complete responses in patients with advanced melanoma who received nivolumab plus ipilimumab (NIVO+IPI) or NIVO alone
    Author: C. Robert
    Abstract: #1082MO
    Mini Oral Session: Melanoma and Other Skin Tumours
    Presentation Time: Friday, September 18 (On-Demand)
  • Nivolumab (NIVO) monotherapy or combination therapy with ipilimumab (NIVO+IPI) in advanced melanoma patients with brain metastases: real-world evidence from the German non-interventional study NICO
    Author: R. Gutzmer
    Abstract: #1104P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
  • Estimating long-term survivorship in patients with advanced melanoma treated with immune-checkpoint inhibitors: analyses from the phase 3 CheckMate 067 trial
    Author: P. Mohr
    Abstract: #1105P
    E-Poster Display ( Presentation Time: Thursday, September 17 (On-Demand)
  • Long-Term Outcomes of Stage IIB-IV Melanoma Patients: Nationwide Data From Norway
    Author: A. Winge-Main
    Abstract: #1150P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)

Early Assets
  • CC-90010, a reversible, oral bromodomain and extra-terminal (BET) inhibitor in patients (pts) with advanced solid tumors (STs) and relapsed/refractory (R/R) non-Hodgkin lymphoma: updated results of a phase 1 study
    Author: V. Moreno
    Abstract: #527O
    Proffered Paper Session: Developmental Therapeutics, Channel 3
    Presentation Time: Sunday September 20, 17:16-17:28 CEST
  • CC-90011 in patients (Pts) with advanced solid tumors (STs) and relapsed/refractory non-Hodgkin lymphoma (R/R NHL): updated results of a phase I study
    Author: A. Hollebecque
    Abstract: #5280
    Proffered Paper Session: Developmental Therapeutics, Channel 3
    Presentation Time: Sunday, September 20, 17:28-17:40 CEST
  • Phase 1b study of CC-90011 plus etoposide and cisplatin (EP) in patients with first-line extensive-stage (ES) small cell lung cancer (SCLC)
    Author: L. Paz-Ares
    Abstract: #559P
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)

Safety
  • Pan-Tumor Study CheckMate 8TT for Long-term Follow-up of Cancer Survivors Who Have Participated in Trials Investigating Nivolumab​
    Author: C. Denlinger
    Abstract: #1155TiP
    E-Poster Display
    Presentation Time: Thursday, September 17 (On-Demand)
Source: "Bristol Myers Squibb Research At ESMO Virtual Congress 2020 Highlights Significant Progress In Cancers With High Unmet Medical Need". 2020. News.Bms.Com.

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