EAU 2018: Is There a Relationship Between The Microbiota of Urine and Intestines in Patients With Acute Obstructive Pyelonephritis

Copenhagen, Denmark (UroToday.com) It is well known that the human body hosts a variety of microbial cells. However, the relationship between different microbiota on different areas on and inside the body are not fully understood. The authors stated that they believe that microbiota of various areas are interrelated and they sought to study the changes in microbiota from the urine and feces in patients with acute obstructive pyelonephritis (AOP).

For this study, urine and feces (intestine) was obtained from 60 women with AOP that had no antibiotic treatment until urgent hospitalization. The samples obtained were used to cultivate bacteria on nutrient media for examination. The same procedures were followed for 24 healthy women without AOP to act as a control group. All were tested for E. Coli, Hemolytic E. Coli, lactose-negative E. coli, coagulase-negative staphylococci (CNS), Enterococci, Peptostreptococci, and Lactobacillus. Detection frequency and average concentration was calculated for all.

Typical E. coli in the urine showed no changes in frequency but showed higher concentration in patients with AOP compared to healthy patients. Typical E. coli in the intestines showed higher frequency and concentration for the healthy group. High concentrations for hemolytic (heme) and lactose-negative (L-) E. coli were seen in the urine of AOP patients. High concentrations were also seen for heme and L- in the intestines with greater frequency and concentration for AOP patients compared to healthy. Frequency and concentration for Lactobacilli decreased for both urine and intestine for AOP patients.
In CNS, Enterococci, and Peptostreptococci all showed decreases in concentration in the intestines. From this data the authors concluded that AOP development may be associated with E. Coli concentration in the urine and believe that it may derive from the intestines.

Speaker: Y. Naboka

Authors: Naboka Y., Kogan M., Gudima I., Mitusova E., Bedjanian S., Ivanov S.

Written by: Renai Yoon, Department of Urology, University of California-Irvine, at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark
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