AUA 2019: Immediate Preoperative Blood Glucose and Hemoglobin A1c levels are not Predictive of Post-operative Infections in Diabetic Men Undergoing Penile Prosthesis Placement

Chicago, IL ( Mohamad Mahdi Osman, a researcher from UC Irvine presented on preoperative blood glucose and hemoglobin A1c in relation to post-operative penile prosthesis infections in diabetic men. Pre-operative blood glucose levels are typically recognized as a predictive factor for infection rates in patients undergoing penile prosthesis (PP) implantation. Osman stated that the goal of the study was to determine whether preoperative blood glucose and hemoglobin A1c levels are indeed associated with post-operative PP infections in diabetic men.

This was a retrospective study on 758 diabetic men undergoing primary PP placement across 17 institutions. Osman highlights that this is currently the largest database on diabetic patients with PP placement. Pre-operative serum blood glucose (PBG) and HbA1c levels were assessed, along with covariates of age, diabetes type, diabetes-related complications, BMI, prosthesis type, Charlson Comorbidity Index, history of immunosuppression and prior radical prostatectomy were evaluated as well. All variables were assessed for primary outcomes of post-operative infection, and secondary outcomes of revision and explantation rates.

They found that preoperative blood glucose and HbA1c levels were not predictive of postoperative infection, revision, or explanation rates. Additionally, no significant predictors were found in multivariate analysis in predicting risks of explanation and revision. However, Osman emphasized that they did find that on multivariate analysis, patients with a history of diabetes-related complications (neuropathy, retinopathy, etc.) are at an increased risk for postoperative infection by about 3 times.

Presented by: Mahdi Osman, MD, Researcher, Department of Urology, University of California-Irvine, Irvine, California

Written by: Kaelyn See, Department of Urology, University of California-Irvine, at the American Urological Association's 2019 Annual Meeting (AUA 2019), May 3 – 6, 2019 in Chicago, Illinois