AUA 2017: Specific changes in brain activity in women with overactive bladder after successful sacral neuromodulation with Interstim: An fMRI study.

Boston, MA ( The study aim was to measure changes in brain activity associated with sacral neuromodulation (SNS) treatment of OAB.  It was hypothesized that SNS treatment with attenuate pre-existing areas of increased brain activity. 

This was prospective study of women undergoing InterStim for refractory OAB (n=12, mean age 63.5).  Two fMRI exams were completed during bladder filling pre Interstim and post Interstim stage II implant.  During the MRI, bladder was filled with saline and patient was asked to signal experiences of urgency.  Pre-TX brain activity, mean ICIQ FLUTS filling scores was 10.  Brain activity decreased in several regions after treatment including the insula, ACC and prefrontal cortex.  There were no increased brain activity after InterStim.  The authors concluded that SNS TX with InterStim appears to attenuate brain activity in regions involved in the micturition pathway and this TX does not lead to areas of ne brain activity.  So patients with great pretreatment brain activity may have more optimal responses to InterStim.

Presented by: Steven Weissbart, MD, Long Island Jewish

Written by: Diane K. Newman, DNP, FAAN, BCB-PMD, Perelman School of Medicine, University of Pennsylvania

at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA