AUA 2017: Differential gene expression in patients with indolent versus aggressive chromophobe renal cell carcinoma: An analysis of the cancer genome atlas database

Boston, MA ( This re-analysis of the TCGA database stratified patients by their overall survival after being diagnosed with chromophobe RCC. In the analysis, 200 overexpressed genes were identified in patients who deceased after diagnosis. The study further identified that the majority of the overexpressed genes were related to cell replication and cell cycle (56%), followed by DNA repair (9%), and intracellular metabolism (7.5%).

The TCGA has uncovered a litany of molecular information regarding RCC. In particular, chromophobe RCC has been observed to follow divergent clinical courses. Although the intention of the study to identify meaningful molecular mechanisms underlying aggressive behavior by chromophobe RCC is important, it may not be sufficient to use such a simplistic method by stratifying according to overall survival. Nonetheless, the identified differentially expressed genes are of interest and can potentially be used to elucidate the mechanisms of disease progression.

Presented By: Alp Tuna Beksac, MD

Written By: Roger Li MD Urologic Oncology Fellow, UT MD Anderson Cancer Center @UrogerliMD
Ashish M. Kamat MD Wayne B. Duddlesten Professor, UT MD Anderson Cancer Center

at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA