AUA 2017: Can partial nephrectomy provide equal oncological efficiency and safety compared with radical nephrectomy in patients with renal cell carcinoma (≥ 4 cm)? A propensity score matched study

Boston, MA ( Continued debate remains in the realm of partial versus radical nephrectomy for larger renal masses. This Korean group helped attack this topic using a matched propensity score analysis. They retrospectively analyzed over 2300 patients who underwent surgery for cT1b or T2 RCC, and sought to comparing progression free, cancer specific, and overall survivals for patients.

After accounting for clincopathologic characteristics using propensity score matching, no significant differences were demonstrated were in any of the survival outcomes for radical and partial nephrectomy (all p>0.05). However, increased in 30 day complications were identified in the partial nephrectomy cohort (p<0.001). A sub-analysis of cT2 tumors only also demonstrated no differences in survival outcomes.

This study supports radical nephrectomy in this cohort, due to the less perioperative complications. However, even with the use of matched propensity models, selection and unaccounted biases do exist. Future prospective studies will continue to shed information on this controversial topic.

Presented By: Hyunwoo Chung

Authors: Hakmin Lee, Hyun Woo, Ohseong Kwon, Jong Jin Oh, Seok-Soo Byun, Chang Wook Jeong, Cheol Kwak, Hwang Gyun Jeon, Byong Chang Jeong, Seong Soo Jeon, Hyun Moo Lee, Han-Yong Choi, Seong Il Seo

Institution: Sungkyunkwan University School of Medicine, Seoul, Korea

Written By: David B. Cahn, DO, MBS, Fox Chase Cancer Center
Twitter: @dbcahn

at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA