It is perplexing why so few P-MIBC patients were found. This may be a clue to a more important conclusion: that RC is underused for patients failing intravesical therapy. Although no survival benefit was demonstrated in the P-MIBC patients undergoing neoadjuvant chemotherapy, this may simply be the effect of inadequate numbers included in the analysis. However, emerging evidence from MSKCC suggest that P-MIBC have different molecular signatures than de novo MIBC, which may explain their lack of response to chemotherapy. Further studies are needed to place this finding within the context of the molecular subtyping of urothelial carcinoma.
Presented by: Raj Bhanvadia, University of Chicago
Written By: Roger Li MD Urologic Oncology Fellow, Department of Urology, UT MD Anderson Cancer Center, Houston, TX
Ashish M. Kamat MD Wayne B. Duddlesten Professor, Department of Urology, UT MD Anderson Cancer Center, Houston TX
at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA