VAIL, CO USA (UroToday.com) - Objectives: Radical prostatectomy (RP), brachytherapy, cryosurgical ablation and intensity-modulated radiotherapy (IMRT) are accepted treatment options for localized prostate cancer.
The objectives of this study are to determine the overall survival (OS), disease specific survival (DSS) and biochemical no evidence of disease (BNED) of the patients who underwent these different treatment modalities.
Materials and Methods: A total of 485 patients with localized prostate cancer treated with RP (n=235), brachytherapy (n=202), cryosurgical ablation (n=33), and IMRT (n=15) were identified from the database of a single urological practice. Analysis of variance (ANOVA) was used to compare means of patients. Chi-square test was used to compare percentage. Kaplan-Meier survival analysis was used to determine if the outcome parameters significantly differ according to the methods. P-values less than 0.05 indicate significant difference. All the statistical tests were performed using SPSS 20.0.
Results: The OS after RP, brachytherapy, cryosurgical ablation and IMRT were 97.9%, 89.1%, 93.9% and 93.3%, respectively. The DSS was 99.6%, 98.0% and 97.0%. respectively. No mortality from prostatic cause was reported from IMRT. The BNED was 90.6%, 88.1%, 78.8% and 93.3%, respectively.
Conclusion: The overall and disease specific survival were comparable among all treatment modalities. Although brachytherapy and IMRT showed an overall better BNED outcome, this advantage disappeared when the patients are analyzed in accordance to their respective risk stratification into low, moderate and high risk group.
Presented by Marlon P. Martinez and Jason L. Letran at the 24th International Prostate Cancer Update - February 19 - 22, 2014 - Cascade Conference Center - Vail, Colorado USA
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