INTERVIEW WITH NOEL CLARKE
Treating the Primary in High vs Low Volume Hormone Sensitive Disease

INTERVIEW WITH DECLAN MURPHY
Imaging Modalities to Treat Node-Positive Disease

INTERVIEW WITH FRED SAAD
The Risk of Dose De-intensifying Treatment, Bone Health in Prostate Cancer

INTERVIEW WITH COLIN PRITCHARD
Integrating Genomics and Genetics into Clinical Care for Prostate Cancer, A Pathologist's Perspective

Videos
State-of-the-industry video lectures by leading urology experts
Featured Videos

Optimizing collagenase Clostridium histolyticum therapy for Peyronie's disease using a novel approach with percutaneous needle tunnelling.

To compare the efficacy and safety of a combined treatment of percutaneous needle tunnelling (PNT) and a modified collagenase Clostridium histolyticum (CCH) protocol (PNT/CCH) vs the modified protocol alone (CCH) in the treatment of Peyronie's disease (PD).

A prospective registry of patients treated with a modified CCH protocol was maintained between June 2014 and February 2018. The last 50 patients received PNT as an adjuvant therapy (PNT/CCH), and their data were compared with those of the other 94 patients treated previously (CCH). PNT involves the creation of multiple holes made percutaneously in the plaque before each injection. The modified protocol consisted of two collagenase injections, at 1-week intervals, followed by penile modelling. Patients used penile traction therapy, tadalafil and pentoxifylline for the next 2 months and were followed up for 6 months. The main outcome was improvement of curvature. Secondary outcomes were improvements in erectile function, PD symptoms, stretched penile length and satisfaction.

Improvement in curvature was greater in patients in the PNT/CCH group than in the CCH group (mean ± sd 19.2 ± 6.1° vs 12.7 ± 5.0°; P < 0.001 [36.2 ± 12.5% vs 28.1 ± 14.5%; P = 0.001]). Compared with baseline, both interventions were associated with significant improvement in secondary outcomes. The main complications were ecchymosis, bruising and penile pain, with no significant differences between groups.

Treatment of PD with CCH using our modified protocol in combination with PNT is safe and more effective than the modified protocol alone, with the potential for improved cost-effectiveness.

BJU international. 2019 Apr 29 [Epub ahead of print]

Esaú Fernández-Pascual, Francisco Javier González-García, Javier Angulo, Eugenio Cerezo, Luis M Quintana, Jorge Turo, Claudio Martínez-Ballesteros, Joaquín Carballido, Juan Ignacio Martínez-Salamanca

Department of Urology, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain., Lyx Institute of Urology, Madrid, Spain., Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.

Conference Coverage
 
Recent data from conferences worldwide
  • 2019 Annual Congress / October 17 - October 20 / Athens, Greece
  • 2019 Annual Meeting / October 3 - October 5 / Aarhus, Denmark
  • 2019 Annual Congress / September 27 - October 1 / Barcelona, Spain
  • 2019 Biennial Meeting / August 29-31 / Basel, Switzerland
  • 2019 Think Tank / August 8-10 / Washington, DC
  • 2019 Annual Meeting / May 31 - June 6 / Chicago, IL
  • 2019 Annual Meeting / May 3-6 / Chicago, IL
  • 2019 World Congress / May 1-3 / Liverpool, United Kingdom
  • 2019 Symposium / April 1-4 / Ottawa, ON
Journals
Publications focusing on urologic cancer treatments through original manuscripts
E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe