Condition: Prostate Cancer

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02918253

Sponsor: University Health Network, Toronto

Eligibility:

• Age: minimum 18 Years maximum N/A
• Gender: All

Inclusion Criteria:

• Age ≥ 18 years
• ECOG performance status 0
• 2
• Histological evidence of prostate adenocarcinoma
• Low- and favorable intermediate-risk prostate cancer
• Informed consent: All patients must sign a document of informed consent indicating their understanding of the investigational nature and risks of the study before any protocol related studies are performed
• No contraindications to MRI:
• Absent or unifocal intraprostatic disease (<2 separate/distinct lesions), on multiparametric MRI
• Prostate gland size <80cc
• Baseline IPSS <18
• No TRUP within the past 6 months, nor large TURP defect
• Absence of radiological evidence of regional or distant metastases (optional evaluation, at physician discretion)
• No previous pelvic and/or prostate EBRT and/or brachytherapy
• No contraindications to general anesthesia, or spinal/epidural anesthesia
• Absence of bleeding diathesis and/or anti-coagulative therapy that cannot be temporarily ceased during brachytherapy
• No contraindications to endorectal coil, surgically absent rectum, severe hemorrhoids or colorectal surgery
• Negative past medical history of Ulcerative Colitis, Crohn's Disease, Ataxia Telangiectasia, or SLE
• Absence of latex allergy
• No other medical conditions deemed by the PI to make patient ineligible for prostate HDR brachytherapy

View trial on ClinicalTrials.gov