Testicular Cancer
Metastatic Testicular Germ Cell Tumor in a Patient With Neurofibromatosis Type 1: Treatment With Trametinib Based on NF1 Gene Mutation.
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Neurofibromatosis type 1 (NF1) is a genetic disorder that increases the risk of various tumors. However, its association with testicular germ cell tumors (GCTs) is rare. We report a case of metastatic GCT in an NF1 patient treated with precision medicine.
Cannabis use and testicular germ cell tumour subtypes in the french nationwide TESTIS case-control study.
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Testicular germ cell tumours (TGCTs) are the most common malignancy among young men, and their rapidly increasing incidence suggests a role for modifiable risk factors. The role of increasingly prevalent cannabis use, particularly during developmental periods before biological maturation, in TGCT etiology remains unclear.
Driving precision medicine in testicular germ cell tumors: from preclinical models to clinical applications.
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Testicular cancer is the most common cancer in young adult men, and its incidence is increasing globally, with testicular germ cell tumors (TGCT) being the most frequent subtype. These tumors show remarkable sensitivity to cisplatin, but there is a small subset of patients that develop resistance to the therapy, experiencing low quality of life and having no treatment options.
Proton Beam Therapy for Testicular Seminoma: Clinical Outcomes and Toxicity From the Proton Collaborative Group Prospective Registry.
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Testicular seminoma predominantly affects young men, and while photon-based radiotherapy achieves excellent disease control, concerns about late effects, including secondary malignancies, have driven interest in proton beam therapy (PBT) as a way to improve dose conformality and spare normal tissue.
Prognostic Reclassification and Survival Outcomes in Intermediate-Risk and Poor-Risk Nonseminomatous Germ Cell Tumors: Single-Institution Experience From Western India.
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Intermediate-risk and poor-risk nonseminomatous germ cell tumors (NSGCTs) have inferior survival outcomes compared with earlier stages. This study reports the survival outcomes and proposes a prognostic reclassification to identify the poorest risk subset within these groups.
A novel classification of testicular sex cord-stromal tumours from the Testicular Sex Cord-Stromal Tumour (TESST) group: a collaboration of the Genitourinary Pathology Society (GUPS) and the International Society of Urological Pathology (ISUP).
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Testicular sex cord-stromal tumours (TSCSTs) are rare neoplasms that arise from (or show differentiation to) elements derived from the sex cords or intertubular stroma. The current classification (World Health Organization, 2022) is based almost entirely on morphology, with many tumour types such as granulosa cell tumours being defined based on their resemblance to ovarian counterparts.
Testis-sparing surgery for small testicular masses: Functional and oncological outcomes.
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To evaluate functional and oncological outcomes of testis-sparing surgery (TSS), particularly in selected patients with small testicular masses (STMs), including those with a normal contralateral testis and germ cell tumors.
Presentation, Management, and Outcomes of Testicular Germ Cell Tumors by Age - Beyond the Abstract
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Human iPSCs derived from cryopreserved testicular somatic cells enable germline regeneration in childhood cancer survivors.
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Can cryopreserved primary testicular somatic cells from childhood cancer survivors with severely decreased fertility potential be reprogrammed into human-induced pluripotent stem cells (hiPSCs) competent for efficient specification into early human germ cells?
Primary testicular somatic cells from cryopreserved testicular samples with severely compromised spermatogonial pools can be reprogrammed into hiPSCs using a non-genome-integrating, feeder-free approach and subsequently differentiated into human primordial germ cell-like cells (hPGCLCs) with high efficiency.
Prognostic Factors for Relapse and Mortality Risk in Chilean Patients With Testicular Cancer: A Retrospective Cohort Study.
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Germ cell tumors (GCTs) are the most common malignancies among young men. In Latin America and the Caribbean, including Chile, population-based data remain limited; however, mortality is consistently reported to be higher than that in other regions.