Testicular, Penile, and Rare GU Malignancies COE

Testicular Cancer Treatment and Cardiovascular Health: Understanding the Long-Term Risks - Khalid Alkhatib

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Zach Klaassen and Khalid Alkhatib discuss the significant cardiovascular risks faced by testicular cancer survivors. Dr. Alkhatib explains that the exact mechanisms behind this increased risk are not fully understood but are thought to be related to chemotherapy, particularly with Cisplatin, and associated conditions like metabolic syndrome and hypogonadism. Their study, utilizing a 15-year nation...

Long-Term Toxicity in Testicular Cancer and AYA: Premature Mortality and Morbidity Illustrated - Zachary Klaassen

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Zach Klaassen discusses his lecture on the topic of testicular cancer and survivorship during a discussion with Alicia Morgans. Highlighting the long-term effects of chemotherapy, Dr. Klaassen emphasizes the profound impact on young patients who often live decades post-diagnosis. His presentation addresses the serious long-term toxicities, noting that one in five survivors experiences significant...

Comparing Cost-Effectiveness of Surgery, Radiation, and Chemo for Seminoma - Daniel Joyce

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Ruchika Talwar interviews Daniel Joyce about his journey into cost-effectiveness studies, particularly in testicular cancer. Initially skeptical, Dr. Joyce now sees these studies as crucial for interpreting clinical trial data in real-world contexts. He discusses his analysis of the SEMS trial, focusing on small-volume stage two seminoma, where RPLND emerged as the most cost-effective option compa...

Testicular Cancer Survivors Find Community and Healing Through Foundation and Patient Summit - Connor O'Leary & Charles Freeman McCluskey

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Zach Klaassen hosts a discussion with Connor O'Leary and Freeman McClusky, both testicular cancer survivors. They delve into the history and mission of Testicular Cancer Foundation (TCF), emphasizing its focus on education, awareness, and support since its inception in 2009. The conversation highlights the importance of community and brotherhood among survivors, with TCF playing a pivotal role in...

Detecting Early Testicular Cancer Relapse with Plasma MicroRNA Analysis - Lucia Nappi

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Zach Klaassen interviews Lucia Nappi about her research on the role of microRNAs in early-stage testicular cancer. MicroRNAs are small RNA fragments crucial for the regulation of oncogenes and tumor suppressors, with certain microRNAs notably overexpressed in testicular cancer. Dr. Nappi's team analyzed the microRNA-371 in plasma samples from stage I testicular cancer patients, finding that patien...

Advancing Care for Rare GU Tumors, Global Society of Rare Genitourinary Tumors - Philippe Spiess

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Philippe Spiess speaks about the Global Society of Rare GU Tumors. The society was founded by him and Andrea Necchi, who realized that rare cancers are underrepresented, particularly in clinical trials and peer-reviewed publications. The society's mission is to advance the care and management of rare GU tumors through global collaborations with the scientific community and patient advocacy. Biogra...

A SEER-Medicare Based Quality Score for Patients with Both Synchronous and Metachronous Metastatic Upper Tract Urothelial Carcinoma - Daniel Joyce

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Daniel Joyce joins Sam Chang to discuss oncologic outcomes, costs, and quality metrics for patients with both synchronous and metachronous metastatic upper tract urothelial carcinoma (mUTUC). Upper tract urothelial carcinoma accounts for around 10% of all urothelial cancer cases that appear. Just around half of those will develop metastatic illness. This work's main objective was to determine what...

The Role of Neoadjuvant Chemotherapy on Pathological Stage and Survival in Sarcomatoid Bladder Cancer – Arya Roy

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Arya Roy joins Alicia Morgans to discuss her work on the role of neoadjuvant chemotherapy on the sarcomatoid variant of bladder cancer. This research earned Dr. Roy a 2023 ASCO GU Merit Award at this year's ASCO Genitourinary Cancers Symposium. Sarcomatoid bladder cancer is an extremely rare and aggressive histological variant with a poor prognosis and limited consensus regarding its management. D...

Atezolizumab in Advanced Penile Cancer With or Without Radiotherapy, PERICLES - Hielke Martijn De Vries

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Hielke Martijn de Vries joins Alicia Morgans to discuss immunotherapy with or without radiation therapy for advanced penile cancer patients, the results of the PERICLES study. PERICLES is a phase II trial investigating atezolizumab +/- radiotherapy for advanced squamous cell carcinoma of the penis. Biographies: Hielke Martijn de Vries, Department of Urology, Netherlands Cancer Institute, Amsterdam...

Penile Squamous Cell Carcinoma Somatic Alterations - W. Michael Korn

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Charles Ryan is joined by Michael Korn, the Chief Medical Officer of Caris Life Sciences, to discuss the study results assessing the comprehensive genomic profiling of penile squamous cell carcinoma (SCC) and the impact of HPV status on immune-checkpoint inhibition-related biomarkers. Using the Caris Life Sciences dataset, this study aimed to report the landscape of somatic alterations and ICI-rel...