mHSPC COE

The Efficacy of Enzalutamide + ADT vs Placebo + ADT in Patients Who Received Prior Antiandrogen Therapy in the ARCHES Study – Neal Shore

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Neal Shore joins Alicia Morgans to discuss his presentation from the American Urologic Association (AUA) annual meeting titled "Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer Patients Who Received Prior Anti androgen Therapy: PostHoc Analysis of ARCHES." This post hoc analysis aimed to evaluate the efficacy of enzalutamide + androgen deprivation therapy (ADT) versus placebo + ADT in...

Overall Survival Results of PEACE-1 a Phase 3 Trial in Men With De Novo Metastatic Castration-Sensitive Prostate Cancer (mCSPC) – Karim Fizazi

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Alicia Morgans and Karim Fizazi discuss the recent analysis of the PEACE-1 study. The PEACE-1 study is a phase 3 trial evaluating abiraterone plus standard of care in M1 disease and local radiation therapy directed to the prostate primary. Dr. Fizazi discusses the study design and the first results he presented at ASCO 2021, specifically treatment with androgen deprivation therapy (ADT), docetaxel...

The Pattern of Metastatic Spread Impact on Efficacy of Enzalutamide - The ARCHES Study Journal Club - Christopher Wallis & Zachary Klaassen

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In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss a publication entitled Efficacy of Enzalutamide Plus Androgen Deprivation Therapy in Metastatic Hormone-Sensitive Prostate Cancer by Pattern of Metastatic Spread: a Post Hoc Analyses of the ARCHES trial . The present study relies upon secondary analysis of the ARCHES trial, a multinational randomized controlled trial th...

Defining the Standard of Therapy for First-Line mHSPC - Lisa Horvath

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In an abstract review session at the 2021 ASCO annual meeting, Lisa Horvath, PhD, MBBS, FRACP, reviewed 3 abstracts: PEACE-1, the SWOG S1216 trial, and the PEACE-III trial. She expanded her conversation about these three abstracts in a discussion with Alicia Morgans, MD, MPH. In the primary conversation about the PEACE-1 trial, Dr. Horvath discussed the main interest, in this phase III trial, to b...

The Addition of TAK-700 to Testosterone Suppression, Its Effect on Survival in mCSPC SWOG 1216 – Neeraj Agarwal

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The SWOG S1216 is a Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 with Androgen Deprivation Therapy + Bicalutamide in Patients with Newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer (mHSPC). Tak is an oral selective nonsteroidal 17, 20-lyase inhibitor that blocks the synthesis of gonadal and adrenal androgens and in this trial the clinical benefit of Tak wi...

Improved Survival for Men Treated With Enzalutamide Added to Testosterone Suppression Who Present With Distant Metastases Years After Diagnosis of mHSPC Journal Club – Christopher Wallis and Zachary K...

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In this Journal Club, Christopher Wallis and Zachary Klaassen highlight a subset analysis from the ENZAMET trial looking at the impact of enzalutamide on survival outcomes in men whose cancer comes back years later after diagnosis. The ENZAMET trial randomly assigned 1,125 metastatic hormone-sensitive prostate cancer (mHSPC) patients from March 31, 2014, to March 24, 2017: 562 in the non-steroidal...

Intensification of Hormonal Therapy for Men With Metachronous Metastatic Hormone-Sensitive Disease – Chris Sweeney

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In a conversation with Alicia Morgans on clinical characteristics of patients with metastatic hormone-sensitive prostate cancer (mHSPC) and identifying subsets of patients to improve personalized treatments, Christopher Sweeney shares data from a European Urology publication Overall Survival of Men with Metachronous Metastatic Hormone-sensitive Prostate Cancer Treated with Enzalutamide and Androge...

First Results of PEACE-1 A Phase 3 Trial with a 2x2 Factorial Design of Abiraterone Acetate plus Prednisone and/or Local Radiotherapy in Men with De Novo Metastatic Castration-Sensitive Prostate Cance...

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In a presentation at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, Karim Fizazi presented the first results of the PEACE-1 trial. PEACE-1 is a phase 3 trial with a 2x2 factorial design of abiraterone acetate plus prednisone and/or local radiotherapy in men with de novo metastatic castration-sensitive prostate cancer. Adding abiraterone to ADT + docetaxel significantly impro...

Practice Patterns of Metastatic Castration-Sensitive Prostate Cancer in the Veterans Healthcare Administration - Stephen Freedland & Scott Tagawa

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In this conversation with Alicia Morgans, MD, MPH, Drs Scott Tagawa and Stephen Freedland highlight real-world evidence of survival outcomes in patients with metastatic castration-sensitive prostate cancer (mCSPC) in the Veterans Health Administration system. Drs. Tagawa, Freedland, and colleagues used the Veterans Health Administration claims data to identify patients with mCSPC who initiated ADT...

The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer - Matthew Deek & Phuoc Tran

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Matthew Deek and Phuoc Tran join Charles Ryan to discuss their recent paper "The Mutational Landscape of Metastatic Castration-Sensitive Prostate Cancer: The Spectrum Theory Revisited" published in European Urology. The aim of this study was to characterize the somatic mutational landscape across the disease spectrum of metastatic castration-sensitive prostate cancer (mCSPC) to elucidate a biologi...
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