Clean intermittent catheterization (CIC) is recommended after spinal cord injury (SCI) because it has the least complications, however, CIC has a high discontinuation rate. We hypothesized that bladder botulinum toxin injection or augmentation cystoplasty may improve satisfaction with CIC.
The NBRG registry is a multicenter, prospective, observational study asking SCI participants about neurogenic bladder (NGB) related quality of life (QoL). In this study, participants performing CIC as primary bladder management were categorized into 3 groups: (1) CIC alone (CIC); (2) CIC with botulinum toxin (CIC-BTX); and (3) CIC with augmentation cystoplasty (CIC-AUG). Outcomes included primary: Neurogenic Bladder Symptom Score (NBSS) and SCI-QoL Bladder Management Difficulties, and secondary: NBSS subdomains (Incontinence, Storage & Voiding, Consequences) and the NBSS final question (satisfaction with urinary function). Multivariable regression, controlling for multiple factors was used to establish differences between the three groups.
Eight hundred seventy-nine participants performed CIC as primary bladder management and had the following characteristics: mean age 43.4 (±12.9) and years from injury 13.7 (±10.7), tetraplegia in 284 (32%), and 543 (62%) were men. Bladder management was CIC in 593 (67%), CIC-BTX in 161 (19%), and CIC-AUG in 125(15%). Primary outcomes: CIC-AUG had associated improved total NBSS versus CIC(-3.2(-5.2 to -1.2), P = 0.001 and CIC-BTX(-3.9(-6.3 to -1.6), P = 0.001), CIC-AUG also had better SCI-QoL Difficulties scores versus CIC(-4(-5.48 to -2.53, P < 0.001) and CIC-BTX(-4.4(-6.15 to -2.65, P < 0.001).
CIC-AUG had associated improved Incontinence and Satisfaction scores versus CIC and CIC-BTX.
Compared to patients performing CIC with or without botulinum toxin treatment, those with augmentation cystoplasty had associated better urinary function and satisfaction with their urinary symptoms.
Neurourology and urodynamics. 2018 Oct 30 [Epub ahead of print]
Jeremy B Myers, Sara M Lenherr, John T Stoffel, Sean P Elliott, Angela P Presson, Chong Zhang, Jeffery Rosenbluth, Amitabh Jha, DarshanP Patel, Blayne Welk, Neurogenic Bladder Research Group (NBRG. org)
Department of Surgery (Urology), University of Utah, Salt Lake City, Utah., Department of Urology, University of Michigan, Ann Arbor, Michigan., Department of Urology, University of Minnesota, Minneapolis, Minnesota., Department of Internal Medicine, University of Utah Division of Epidemiology and Biostatistics, Salt Lake City, Utah., Department of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah., Department of Physical Medicine and Rehabilitation, Salt Lake City Veterans Medical Center, Salt Lake City, Utah., Department of Surgery, University of Western Ontario, London, Ontario, Canada.