Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea - Abstract

With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.

Written by:
Seo MR, Kim SJ, Kim Y, Kim J, Choi TY, Kang JO, Wie SH, Ki M, Cho YK, Lim SK, Lee JS, Kwon KT, Lee H, Cheong HJ, Park DW, Ryu SY, Chung MH, Pai H.   Are you the author?
Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea; Department of Laboratory Medicine, Hanyang University, Seoul, Korea; Department of Clinical Microbiology, Hanyang University, Guri, Korea; Department of Internal Medicine, St. Vincent's Hospital, School of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Preventive Medicine, Eulji University School of Medicine, Daejeon, Korea; Department of Internal Medicine, Gil Hospital, Gacheon University, Incheon, Korea; Department of Internal Medicine, Ajou University Hospital, Suwon, Korea; Department of Internal Medicine, Hallym University, Kangdong Sacred Heart Hospital, Seoul, Korea; Department of Internal Medicine, Daegu Patima Hospital, Daegu, Korea; Department of Internal Medicine, Dong-A University Hospital, Busan, Korea; Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea; Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea; Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea; Department of Internal Medicine, Inha University Hospital, Incheon, Korea.

Reference: J Korean Med Sci. 2014 Aug;29(8):1178-81.
doi: 10.3346/jkms.2014.29.8.1178


PubMed Abstract
PMID: 25120333

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