IRONMAN - A Better Understanding of the Variation in Care and Treatment - Daniel George

(Length of Discussion: 17 min)

Daniel George, MD and Director of GU Oncology talks with Alicia Morgans, MD about the IRONMAN initiative  The project stemmed from the discussion Dr. George had with Dr. Philip Kantoff, MD and Lorelei Mucci, who he worked with on the project, of what is missing in the field of advanced prostate cancer.  Dr. George reflects on the number of phase 3 studies that have come out demonstrating the benefit associated with either secondary hormonal therapies, chemotherapies, radio pharmaceuticals, or immunotherapies, but none of which really dealt with the sequential approach of these agents or any combinations.

Dr. Dan George and his team discussed the realization that there are a lot of different practice patterns emerging in academics, in the community and throughout the world and it dawned on them that there isn’t going to be a phase 3 study that answers all the questions and the more treatment options there are the more advanced the disease is going to be and the more important it is that there is a database of these treatments that are captured in one database, where the sequencing of these treatments can be viewed over time. A place to really understand if one approach is better than another.

The intent of the project was to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Brazil, Canada, Ireland, Sweden, Switzerland, the United Kingdom (UK), and the US.

This cohort study will facilitate a better understanding of the variation in care and treatment of advanced prostate cancer across countries and across academia and community based practices.

Biographies:

Daniel George, MD
Director of GU Oncology, Duke Cancer Institute Professor of Medicine and Surgery, Duke University School of Medicine, Co-Pi, IRONMAN

Alicia Morgans, MD, MPH

Related Content:

Watch: Lorelei Mucci and Philip Kantoff on Outcomes Research and the IRONMAN Project

Watch: International Registry To Improve Outcomes in Men With Advanced Prostate Cancer-IRONMAN- Lorelei Mucci

IRONMAN: An International Registry for Men with Advanced Prostate CancerAn International Registry for Men with Advanced Prostate Cancer

Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men With Advanced Prostate Cancer (IRONMAN)