Penile & Urethral Cancer

The Relationship Between HPV Status and Chemoradiotherapy in the Locoregional Control of Penile Cancer - Beyond the Abstract

The manuscript is timely in that, while the status of HPV infection in oropharyngeal cancer (OPCa) is becoming better defined, and is beginning to modify therapy, the case is not true for penile cancer (PeCa).  The latter is much less common and data on clinical and viral interactions far fewer.

Penile Sparing Surgery for Penile Cancer: A Multicenter International Retrospective Cohort: Beyond the Abstract

In the largest cohort to date, we demonstrate that penile sparing surgery offers durable local control for superficial and select invasive penile tumors at intermediate follow-up.  Although traditional clinical standards would recommend partial or total penectomy for any penile tumor ≥T2, we present a large multicenter study collaboration among international centers of excellence suggesting carefully selected patients with pT2 disease (i.e. small volume, favorable location) can be managed with penile sparing surgery, provided a negative resection margin is achieved.  Approximately 75% of local recurrences after penile sparing surgery occur within the first three years, making judicious follow-up in the early post-operative period imperative. Prospective studies are however still needed to clarify the optimal post-operative surveillance strategy to rigorously adopt among patients undergoing penile sparing surgery.

Written by: Adam Baumgarten

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