Chronic kidney disease after nephrectomy in patients with small renal masses: A retrospective observational analysis - Abstract

CONTEXT: Chronic kidney disease (CKD) is a worldwide health threat associated with increased cardiovascular disease and mortality.

OBJECTIVE: To examine postoperative CKD in patients with small renal masses (SRMs) treated with partial nephrectomy (PN) or radical nephrectomy (RN).

DESIGN, SETTING, AND PARTICIPANTS: A US National Cancer Institute Surveillance Epidemiology and End Results (SEER)-Medicare-linked retrospective cohort of 4633 T1aN0M0 renal cell carcinoma (RCC) patients who underwent PN or RN.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary outcome of interest was the onset of CKD stage ≥3. Secondary end points comprised acute renal failure (ARF), chronic renal insufficiency (CRI), anemia in CKD, and end-stage renal disease (ESRD). Kaplan-Meier and Cox regression analyses were performed.

RESULTS AND LIMITATIONS: Postpropensity matching resulted in 840 RN and PN patients. In multivariable analyses, RN patients were 1.9-, 1.4-, 1.8-, and 1.8-fold more likely to have an occurrence of CKD, ARF, CRI, and anemia in CKD, respectively (all p ≤ 0.004). The risk of ESRD between treatment groups failed to achieve statistical significance (p=0.06).

CONCLUSIONS: PN is associated with more favorable postoperative renal function outcomes relative to RN in the setting of SRMs.

Written by:
Sun M, Bianchi M, Hansen J, Trinh QD, Abdollah F, Tian Z, Sammon J, Shariat SF, Graefen M, Montorsi F, Perrotte P, Karakiewicz PI   Are you the author?
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada

Reference: Eur Urol. 2012 Mar 31
doi: 10.1016/j.eururo.2012.03.051


PubMed Abstract
PMID: 22483407