Clear cell renal cell carcinoma (ccRCC) exhibits extensive immune infiltration, yet the influence of immunological heterogeneity on clinical outcomes remains poorly elucidated.
Addressing the formidable challenge of metastasis suppression in ccRCC treatment.
Use scRNA-seq analysis and immunofluorescent imaging to categorize B cells into sub-clusters based on distinct gene expression profiles.
Identify two significant B cell subpopulations, B cell (HLA-DRA) and B cell (FKBP11); show the upregulation of six genes (DERL3, FKBP11, MZB1, TNFSF13B, MYO9B, and ACAP1) in infiltrating B lymphocytes associated with poor prognosis of ccRCC; find that B cell (HLA-DRA) displays a noteworthy association with ccRCC metastasis and demonstrates relevance to tumor immunity across diverse cancers.
The heterogeneity within B-cell subpopulations may substantially contribute to the metastatic potential of clear cell renal cell carcinoma. The findings provide insights into targeted interventions and improved clinical outcomes.
Cancer investigation. 2026 Jun 21 [Epub ahead of print]
Yuanhong Chen, Chun Guo, Shaoang Huang, Caixia Ling, Wenxian Lin, Zhengfang Liang, Jingjie Zhao, Lingzhang Meng, Yulian Tang, Kun Ye
Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, China., Department of Anatomy, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, China., Department of Nephrology, Tiandong County People's Hospital, Baise, China., School of Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, China., Institute of Cardiovascular Sciences, Guangxi Academy of Medical Sciences & The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China., Department of Urinary Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China., Guangxi Clinical Medical Research Center for Chronic Kidney Disease, Guangxi Academy of Medical Sciences & The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.