Renal cell carcinoma represents the 14th most frequent tumour worldwide, but its incidence is increasing partly due to incidental diagnoses. As a result, these tumours are diagnosed in patients at an increasingly advanced age, often frail and with comorbidities.
Most renal cell carcinoma cases are clear cell carcinoma (80 %), with papillary tumours being the second most frequent histological subtype. The standard of care for localized RCC is surgery, with partial nephrectomy or radical nephrectomy being recommended for T1 and T2 tumours, respectively. Thermoablative strategies have been developed over the past decade for patients who are not amenable to surgery and/or with impaired renal function. Active surveillance remains an alternative in the case of small low-grade renal cell carcinoma. Recent research has evaluated stereotactic ablative body radiotherapy as a well-tolerated and effective treatment for small renal tumours essentially for the management of both T1a and T1b tumours. This article aims to report the recommendations of the Société française de radiothérapie oncologique (SFRO, the French society for radiation oncology) on the role of radiotherapy in the management of localized renal cell carcinoma. These guidelines describe both treatment planning modalities, target volumes, and follow-up procedures. They also focus on the impact of radiotherapy on renal function, and the specific dosimetric constraints to be implemented.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. 2025 Sep 10 [Epub ahead of print]
Nicolas Benziane-Ouaritini, Jennifer Le Guevelou, Stéphane Supiot, Mario Terlizzi, Olivier Chapet, Idir Ouzaid, David Pasquier, Vincent Marchesi, Igor Latorzeff, Paul Sargos
Department of Radiotherapy, Centre azuréen de cancérologie, Mougins, France. Electronic address: ., Radiation Oncology Department, centre Eugène-Marquis, Rennes, France., Radiation Oncology Department, Institut de cancérologie de l'Ouest, Nantes, France., Radiation Oncology Department, Gustave-Roussy, Villejuif, France., Department of Radiation Oncology, centre hospitalier Lyon Sud, Pierre-Bénite, France., Department of Urology, hôpital Bichat, Paris, France., Academic Department of Radiation Oncology, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59000 Lille, France., Centre de recherche en informatique, signal et automatique de Lille (Cristal) UMR 9189, université de Lille, Lille, France; Department of Radiotherapy, Institut de cancérologie de Lorraine, Nancy, France., Oncologie Radiothérapie, groupe Orion, clinique Pasteur, 31300 Toulouse, France., Department of Radiotherapy, institut Bergonié, Bordeaux, France; Amethyst Radiotherapy Group, Paris, France.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/40934605