Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Immune Checkpoint Inhibition Is the New Backbone in First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma.

Recent randomised trials have demonstrated a survival benefit for a front-line ipilimumab and nivolumab combination therapy, and pembrolizumab and axitinib combination therapy in metastatic clear-cell renal cell carcinoma. The European Association of Urology Guidelines Panel has updated its recommendations based on these studies. PATIENT SUMMARY: Pembrolizumab plus axitinib is a new standard of care for patients diagnosed with kidney cancer spread outside the kidney and who did not receive any prior treatment for their cancer (treatment naïve). This applies to all risk groups as determined by the International Metastatic Renal Cell Carcinoma Database Consortium criteria.

European urology. 2019 May 28 [Epub ahead of print]

Laurence Albiges, Tom Powles, Michael Staehler, Karim Bensalah, Rachel H Giles, Milan Hora, Markus A Kuczyk, Thomas B Lam, Börje Ljungberg, Lorenzo Marconi, Axel S Merseburger, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernández-Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Axel Bex

Department of Cancer Medicine, Gustave Roussy, Université Paris-Saclay, Villejuif, France., The Royal Free NHS Trust and Barts Cancer Institute, Queen Mary University of London, London, UK., Department of Urology, Ludwig-Maximilians University, Munich, Germany., Department of Urology, University of Rennes, Rennes, France., Patient Advocate, International Kidney Cancer Coalition (IKCC), Duivendrecht, The Netherlands; Department of Nephrology and Hypertension, Regenerative Medicine Center, University Medical Centre Utrecht, Utrecht, The Netherlands., Department of Urology, University Hospital Plzeň, Plzeň, Czech Republic; Faculty of Medicine in Plzeň, Charles University, Plzeň, Czech Republic., Department of Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany., Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK; Academic Urology Unit, University of Aberdeen, Aberdeen, UK., Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden., Department of Urology, Coimbra University Hospital, Coimbra, Portugal., Department of Urology, University Hospital Schleswig-Holstein, Lübeck, Germany., Division of Urology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara, Italy., Department of Urology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel., Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Malmö, Sweden., Department of Urology, Cabueñes Hospital, Gijón, Spain., Department of Urology, Sunderby Hospital, Sunderby, Sweden., Department of Urology, Royal Free Hospital, Pond Street, London, UK., Department of Urology, Elbe Kliniken Stade, Stade, Germany., Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK; UCL Division of Surgery and Interventional Science, London, UK. Electronic address: .