Imaging of Prostate Cancer Using Fluciclovine

Prostate cancer is the most common cancer and the second leading cause of cancer death in men in the United States. Despite high disease prevalence, diagnosis and surveillance of the disease with conventional imaging are limited typically because of indolent biology. Functional imaging with advanced molecular techniques improves the ability to detect disease. Amino acids are building blocks of proteins, and intracellular transport of amino acids is upregulated in prostate cancer. This review provides a detailed overview of the use of F-18 fluciclovine PET in prostate cancer imaging.

PET clinics. 2017 Jan 23 [Epub]

Bital Savir-Baruch, Lucia Zanoni, David M Schuster

Department of Radiology, Loyola University Medical Center, 2160 South 1st Avenue, Maywood, IL 60153, USA. Electronic address: ., Department of Nuclear Medicine, Policlinico Sant'Orsola-Malpighi, Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 9, Bologna 40138, Italy., Department of Radiology and Imaging Sciences, Emory University Hospital, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA.