NMR-based metabolomics of prostate cancer: a protagonist in clinical diagnostics.

Advances in the application of NMR spectroscopy-based metabolomic profiling of prostate cancer comprises a potential tactic for understanding the impaired biochemical pathways arising due to a disease evolvement and progression.

This technique involves qualitative and quantitative estimation of plethora of small molecular weight metabolites of body fluids or tissues using state-of-the-art chemometric methods delivering an important platform for translational research from basic to clinical, to reveal the pathophysiological snapshot in a single step. This review summarizes the present arrays and recent advancements in NMR-based metabolomics and a glimpse of currently used medical imaging tactics, with their role in clinical diagnosis of prostate cancer.

Expert review of molecular diagnostics. 2016 Mar 09 [Epub ahead of print]

Deepak Kumar, Ashish Gupta, Kavindra Nath

a Centre of Biomedical Research, SGPGIMS Campus , Rae Bareli Road, Lucknow , UP 226014 , India., a Centre of Biomedical Research, SGPGIMS Campus , Rae Bareli Road, Lucknow , UP 226014 , India., b University of Pennsylvania , Philadelphia , PA 19104 , USA.