Although three large randomized prospective clinical trials have demonstrated that postoperative radiotherapy in patients with adverse pathological features reduces prostate-specific antigen recurrence and may decrease clinical failure, this approach has not gained widespread acceptance, likely because the data strongly support such an approach only in men with Gleason ≥7 with positive surgical margins.
European urology. 2015 Oct 12 [Epub ahead of print]
Patrick C Walsh, Nathan Lawrentschuk
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA. University of Melbourne, Department of Surgery and Olivia Newton-John Cancer Research Institute, Austin Hospital and Peter MacCallum Cancer Centre, Melbourne, Australia.