Focal High-intensity Focused Ultrasound Targeted Hemiablation for Unilateral Prostate Cancer: A Prospective Evaluation of Oncologic and Functional Outcomes.

In selected patients with unilateral, organ-confined prostate cancer (PCa), hemiablation of the affected lobe might be feasible to achieve acceptable cancer control with fewer complications.

To assess the oncologic and functional outcomes of focal high-intensity focused ultrasound (HIFU) hemiablation in unilateral organ-confined PCa.

Single-center prospective evaluation of HIFU hemiablation for unilateral organ-confined PCa was performed from July 2009 through December 2013.

Cancer localization was done with transrectal ultrasound-guided biopsy and multiparametric magnetic resonance imaging followed by HIFU hemiablation.

Oncologic outcomes were analyzed with control biopsies and prostate-specific antigen (PSA) measurement. Functional outcomes were assessed with validated questionnaires for genitourinary symptoms.

Of 71 HIFU hemiablation patients, 67 completed the study protocol. The mean age was 70. 2 yr (standard deviation: 6. 8 yr), and median PSA was 6. 1 ng/ml (interquartile range [IQR]: 1. 6-15. 5 ng/ml). Median maximum cancer-core length was 3mm (IQR: 2-10mm), and total cancer length was 6. 5mm (IQR: 2-24mm). Gleason score was 6 (3+3) in 58 patients (86. 6%) and 7 (3+4) in 9 patients (13. 4%). Median follow-up was 12 mo (IQR: 6-50 mo), and at 12 mo, 56 of 67 patients had a negative control biopsy in the treated lobe. At 3 mo, all patients were continent, and potency was maintained in 11 of 21 preoperatively potent patients (confidence interval, 0. 18-0. 69). Complications included 8% Clavien-Dindo grade 2 and 2. 8% grade 3 events.

Focal HIFU hemiablation appears to achieve acceptable oncologic outcomes with low morbidity and minimal functional changes. Longer follow-up will establish future considerations.

This study showed that high-intensity focused ultrasound hemiablation in selected patients with unilateral organ-confined prostate cancer can be used for satisfactory cancer control with minimal effect on genitourinary functions.

European urology. 2015 Jul 08 [Epub ahead of print]

Ernesto R Cordeiro Feijoo, Arjun Sivaraman, Eric Barret, Rafael Sanchez-Salas, Marc Galiano, Francois Rozet, Dominique Prapotnich, Nathalie Cathala, Annick Mombet, Xavier Cathelineau

Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France. , Department of Urology, Institut Montsouris, Université Paris-Descartes, Paris, France.

PubMed

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe