Prognostic model predicting metastatic castration-resistant prostate cancer survival in men treated with second-line chemotherapy - Abstract

BACKGROUND: Several prognostic models for overall survival (OS) have been developed and validated in men with metastatic castration-resistant prostate cancer (mCRPC) who receive first-line chemotherapy.

We sought to develop and validate a prognostic model to predict OS in men who had progressed after first-line chemotherapy and were selected to receive second-line chemotherapy.

METHODS: Data from a phase III trial in men with mCRPC who had developed progressive disease after first-line chemotherapy (TROPIC trial) were used. The TROPIC was randomly split into training (n = 507) and testing (n = 248) sets. Another dataset consisting of 488 men previously treated with docetaxel (SPARC trial) was used for external validation. Adaptive least absolute shrinkage and selection operator selected nine prognostic factors of OS. A prognostic score was computed from the regression coefficients. The model was assessed on the testing and validation sets for its predictive accuracy using the time-dependent area under the curve (tAUC).

RESULTS: The nine prognostic variables in the final model were Eastern Cooperative Oncology Group performance status, time since last docetaxel use, measurable disease, presence of visceral disease, pain, duration of hormonal use, hemoglobin, prostate specific antigen, and alkaline phosphatase. The tAUCs for this model were 0.73 (95% confidence interval [CI] = 0.72 to 0.74) and 0.70 (95% CI = 0.68 to 0.72) for the testing and validation sets, respectively.

CONCLUSIONS: A prognostic model of OS in the postdocetaxel, second-line chemotherapy, mCRPC setting was developed and externally validated. This model incorporates novel prognostic factors and can be used to provide predicted probabilities for individual patients and to select patients to participate in clinical trials on the basis of their prognosis. Prospective validation is needed.

Written by:
Halabi S, Lin CY, Small EJ, Armstrong AJ, Kaplan EB, Petrylak D, Sternberg CN, Shen L, Oudard S, de Bono J, Sartor O.   Are you the author?
Department of Biostatistics and Bioinformatics, and Alliance Statistics and Data Center, Duke University, Durham, NC; Departments of Medicine and Urology, University of California-San Francisco, San Francisco, CA; Division of Medical Oncology, Duke Prostate Center and the Duke Cancer Institute, Durham, NC; Departments of Medical Oncology and Urology, Yale University Cancer Center, New Haven, CT; Department of Medical Oncology, San Camillo and Forlanini Hospital, Rome, Italy; Sanofi, Malvern, PA; Department of Medical Oncology, Georges Pompidou European Hospital, Paris, France; Department of Clinical Studies, Royal Marsden Hospital and Institute of Cancer Research, Surrey, United Kingdom; Urology Department, Tulane Cancer Center, New Orleans, LA.

Reference: J Natl Cancer Inst. 2013 Oct 17. Epub ahead of print.
doi: 10.1093/jnci/djt280

PubMed Abstract
PMID: 24136890 mCRPC Treatment Section