AUA 2011 - Evaluation of the prostate health index (PHI) in the 2 to 4, and 4 to 10 ng/ml PSA ranges: Results from a multi-site, prospective, clinical evaluation - Session Highlights

WASHINGTON, DC USA ( - Dr. William Catalona reported that the operating characteristics of the prostate health index (phi) shows improved discrimination of cancer from benign disease compared to PSA and %free PSA.

These investigators assessed the operating characteristics of Beckman Coulter phi in the 2-4 and 4-10ng/mL PSA ranges. The Receiver Operating Characteristics (ROC) curve of phi was evaluated and compared to those of %free PSA and total PSA. Two hundred thirty four men with PSA 2-4ng/mL and 658 men with PSA 4-10ng/mL were enrolled at 7 sites. Participants were ≥50 years, had a non-suspicious DRE, a biopsy- confirmed diagnosis. The PSA, free PSA, and [-2]proPSA concentrations were all determined using the Beckman Coulter Access 2 Immunoassay Analyzer. The Beckman Coulter phi was calculated as ([-2]proPSA/free PSA)x(PSA)).

They found the AUC for phi comparable in both PSA ranges; AUC= 0.708 for the PSA 4-10ng/mL range, and AUC= 0.701 for the PSA 2-4ng/mL range. The combined AUC for the 2-10 PSA range was AUC = 0.703. The AUC for phi was significantly better in the established PSA range of 4-10ng/mL with the AUC for PSA=0.516 (<0.001), and %free PSA=0.648 (0.009). He concluded that that phi has improved clinical specificity compared to PSA and %free PSA and may be useful for aiding biopsy decisions and patient management.


Presented by William J. Catalona, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA

Reported for UroToday by Christopher P. Evans, MD, FACS, Professor and Chairman, Department of Urology, University of California, Davis, School of Medicine.


The opinions expressed in this article are those of the Contributing Editor and do not necessarily reflect the viewpoints of the American Urological Association.



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