While the ProtecT randomized trial demonstrated comparable oncologic outcomes between radical prostatectomy (RP) and radiation therapy (RT) for localized prostate cancer, several retrospective studies have reported mixed findings. In this study, we investigated whether nonrandomized studies tend to favor RP or RT and assessed whether the specialty of leading authors-urologists or radiation oncologists-correlates with study conclusions.
We identified nonrandomized clinical studies published between 1993 and 2024 that compared RP and RT for localized prostate cancer and reported oncologic outcomes including biochemical, metastasis, and/or survival outcomes. Author specialty was determined based on whether the first and senior authors were affiliated with urology or radiation oncology departments. Studies in which a urologist and radiation oncologist were first and senior authors were excluded. Each study's conclusion was categorized as favoring surgery, favoring radiation, or reporting no conclusive difference in oncologic outcomes. Multivariate logistic regression was used to evaluate predictors of study conclusions.
A total of 105 studies met inclusion criteria. Nearly half (44%) reported no conclusive difference in outcomes, while 42% favored RP and 14% favored RT. Multivariate analysis showed that use of national databases (p = 0.01) and urology author specialty (p = 0.01) predicted conclusions aligning with the author's specialty. In a subgroup excluding studies relying solely on biochemical recurrence free survival outcomes, author specialty remained associated with conclusions, with urologists more likely to favor RP (p = 0.006).
Author specialty was associated with the direction of study conclusions. Further research is needed to understand how these patterns may influence interpretation and decision-making in prostate cancer treatment.
We reviewed over 100 studies comparing surgery and radiation for localized prostate cancer and looked at whether certain study features influenced the results. We found that the type of study and the specialty of the doctors writing the paper were linked to which treatment they concluded was better. These results highlight the importance of discussing treatment options with a multidisciplinary team that includes both urologists and radiation oncologists before making a decision.
JNCI cancer spectrum. 2026 Jul 01 [Epub ahead of print]
Zakaria El Kouzi, Mohammed A Mohammed, Michael Kevin Rooney, Ramez Kouzy, Jie Jane Chen, Shalin Shah, Tarek Al Bitar, Sherif M Gadoue, Comron Hassanzadeh, Steven Frank, Phuoc Tho Tran, Chad Tang, Seungtaek Choi, Ryan Jin-Hyung Park, Karen Hoffman, Sean Eric McGuire, Henry Mok, Quynh-Nhu Nguyen, Adam B Samman, Zain Rahman, Mohamed Shelan, Toufic Eid, Osama Mohamad
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston TX, USA., Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh PA, USA., Department of GU Radiation Oncology, University of Texas MD Anderson Cancer Center Houston TX, USA., Department of Radiation Oncology, University of California San Francisco., Department of Radiation Oncology, American University of Beirut Medical Center, Beirut Lebanon., Trinity University, San Antonio, TX, USA., Department of Radiation Oncology, Inselspital Bern, University of Bern, Bern, Switzerland.