The objective was to develop prognostic models that included convolutional neural networks (CNN) derived from 18F-DCFPyL (PSMA) PET imaging of the primary tumor uptake patterns to prognose early metastatic progression after curative intent treatment for localized prostate cancer.
Due to the lack of sufficient cases with adequate follow-up and metastatic events to derive this model directly, we derived models that predict the presence of synchronous metastases using only data obtained from the primary tumor. Because early metastatic progression events are consequent to occult metastases present at the time of initial therapy, we hypothesized that a model trained to predict synchronous metastases might also predict metachronous metastatic progression. A convolutional neural network (CNN) model was generated using whole-prostate PSMA PET images and auto-segmented intraprostatic lesions and combined with clinicopathologic data and imaging parameters to develop a multimodal model. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC) for predicting synchronous metastases and metachronous metastatic progression.
The multimodal model and CNN model had AUCs of 0.82 (95% CI 0.69-0.92, p < 0.005) and 0.72 (95% CI 0.55-0.84, p 0.0059), respectively, for prediction of synchronous metastases. Shapley additive explanation analysis showed the CNN had the largest contribution to the combined model performance. For metastatic progression, the multimodal model had an AUC of 0.839 (95% CI: 0.6763-1.000, p = 0.0064).
The multimodal model trained to predict synchronous metastases also predicted metachronous metastatic progression. This supports the potential of artificial intelligence applied to primary tumor PSMA PET images for enhanced prognostication. However, significant limitations include the modest sample size, single center source of data, and potential for overfitting, which may limit generalizability. Therefore, further validation in a larger cohort is indicated.
PloS one. 2026 Jun 05*** epublish ***
Jesus E Juarez Casillas, Maryam Nezafat, Cecil M Benitez, Kamil Rzechowski, Nathanael Kane, Karl Sjöstrand, Aseem Anand, Ida Sonni, Gholam R Berenji, Sai Duriseti, Matthew B Rettig, Nicholas G Nickols
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America., Exini Diagnostics (subsidiary of Lantheus Holdings, Inc), Bedford, Massachusetts, United States of America., Department of Radiation Oncology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States of America., Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America.