The NCCN Guidelines for Prostate Cancer include recommendations for staging and risk assessment after a prostate cancer diagnosis and for the care of patients with localized, regional, recurrent, and metastatic disease. These NCCN Guidelines Insights summarize the panel's discussions on select 2026 updates to the guidelines regarding nonmetastatic disease: the elimination of the very-low-risk group, updates to the Principles of Active Surveillance, and caution in the use of focal therapy in newly diagnosed patients.
Journal of the National Comprehensive Cancer Network : JNCCN. 2026 May [Epub]
Daniel E Spratt, Sandy Srinivas, Nabil Adra, Bilawal Ahmed, Yi An, Rhonda Bitting, Brian Chapin, Heather H Cheng, Steve Y Cho, Anthony Victor D'Amico, Neil Desai, Tanya Dorff, James A Eastham, Thomas A Farrington, Xin Gao, Shilpa Gupta, Joseph E Ippolito, R Jeffrey Karnes, Amar U Kishan, Michael R Kuettel, Joshua M Lang, Daniel Lee, Tamara Lotan, Andrew McDonald, Todd M Morgan, Rodrigo Pessoa, Soroush Rais-Bahrami, Mack Roach, Tyler Robin, Stan Rosenfeld, Kristen R Scarpato, Tyler Seibert, Ahmad Shabsigh, Russell Szmulewitz, Benjamin A Teply, Jonathan Tward, Richard Valicenti, David VanderWeele, Jessica Karen Wong, Emily Kovach, Deborah Freedman-Cass
1Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute., 2Stanford Cancer Institute., 3Indiana University Melvin and Bren Simon Comprehensive Cancer Center., 4The University of Tennessee Health Science Center., 5Yale Cancer Center/Smilow Cancer Hospital., 6Duke Cancer Institute., 7The University of Texas MD Anderson Cancer Center., 8Fred Hutchinson Cancer Center., 9University of Wisconsin Carbone Cancer Center., 10Dana-Farber/Brigham and Women's Cancer Center | Mass General Cancer Center., 11UT Southwestern Simmons Comprehensive Cancer Center., 12City of Hope National Cancer Center., 13Memorial Sloan Kettering Cancer Center., 14Prostate Health Education Network (PHEN)., 15Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine., 16Mayo Clinic Comprehensive Cancer Center., 17UCLA Jonsson Comprehensive Cancer Center., 18Roswell Park Comprehensive Cancer Center., 19Abramson Cancer Center at The University of Pennsylvania., 20Johns Hopkins Kimmel Cancer Center., 21O'Neal Comprehensive Cancer Center at UAB., 22University of Michigan Rogel Cancer Center., 23Moffitt Cancer Center., 24UCSF Helen Diller Family Comprehensive Cancer Center., 25University of Colorado Cancer Center., 26University of California San Francisco Patient Services Committee Chair., 27Vanderbilt-Ingram Cancer Center., 28UC San Diego Moores Cancer Center., 29The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute., 30The UChicago Medicine Comprehensive Cancer Center., 31Fred & Pamela Buffett Cancer Center., 32Huntsman Cancer Institute at the University of Utah., 33UC Davis Comprehensive Cancer Center., 34Robert H. Lurie Comprehensive Cancer Center of Northwestern University., 35Fox Chase Cancer Center., 36National Comprehensive Cancer Network.