OncoEducate is a clinician-supervised generative artificial intelligence (AI) application designed to deliver standardized, regimen-level, plain-language education at the point of care. We developed a templated handout generator using a locked prompt and predefined content structure that incorporates diagnosis, treatment regimen, and treatment intent, with clinician review prior to patient distribution. We then conducted a prospective, two-phase pilot at a single academic cancer center. In Phase I, six clinicians evaluated AI-generated handouts for nine commonly used palliative-intent genitourinary (GU) oncology regimens using 7-point Likert-scale items. In Phase II, patients with advanced kidney, prostate, or urothelial cancers initiating palliative-intent therapy received clinician-reviewed handouts and completed follow-up surveys at the next office or infusion visit or by telephone when in-person completion was not feasible. Clinicians rated handouts as useful (median 6/7) and accessible (median 6.5/7), with median accuracy ratings of 6-7/7 across domains. During an 8-week period, 20 of 21 approached patients enrolled (95%). Patients rated handouts as informative and readable (median 7/7 for both), and 65% correctly identified treatment intent as palliative. These findings support the feasibility and acceptability of clinician-reviewed, templated AI-generated handouts in routine GU oncology care, justifying larger randomized studies to evaluate clinical impact.
The oncologist. 2026 Apr 09 [Epub ahead of print]
Henry K Litt, Amelia Wodzinski, Pearl Subramanian, Mackenzie Donovan, Neha Vapiwala, Vivek Narayan, Lin Mei, Samuel Takvorian, Naomi B Haas, Ravi B Parikh, Ronak Mistry, Ronac Mamtani
Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Pennsylvania, PA, USA., Abramson Cancer Center, University of Pennsylvania, Pennsylvania, PA, USA., Department of Medicine, University of Pennsylvania, Pennsylvania, PA, USA., Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.